ArticleWorld journal of gastroenterology2008
Recent advances in the management of radiation colitis.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 93 citations in OpenAlex.
- A Case of Late Radiation-Induced Enteritis with Enterolith Caused Enterocutaneous Fistula.Surgical case reports · 2026Article
- Metformin and butyrate attenuate chronic radiation proctitis by alleviating inflammation and macrophage senescence.Frontiers in immunology · 2026Article
- Article
- Utilizing CT imaging for evaluating late gastrointestinal tract side effects of radiotherapy in uterine cervical cancer: a risk regression analysis.BMC medical imaging · 2024Article
- Radiation in Gastroenterology.Gastroenterology research · 2022Review
- The Impact of Postoperative Radiotherapy on Dietary Function of Head and Neck Cancer Patients after Pharyngoesophageal Reconstruction with Free Jejunal Flap.Journal of clinical medicine · 2022Article
- Platelet glycoprotein Ibα provides radiation protection.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2022Article
- Research progress on the mechanism of radiation enteritis.Frontiers in oncology · 2022Review
- Article
- Expansion of monocytic myeloid-derived suppressor cells ameliorated intestinal inflammatory response by radiation through SOCS3 expression.Cell death & disease · 2021Article
- Diverting colostomy is an effective procedure for ulcerative chronic radiation proctitis patients after pelvic malignancy radiation.BMC surgery · 2020Article
- Endoscopical and pathological dissociation in severe colitis induced by immune-checkpoint inhibitors.Oncoimmunology · 2020Article
- Acute Onset of a Swollen Leg With Crepitus: A Complication With Rectal Perforation.Journal of acute medicine · 2019Article
- Adhesion Ileus after Fecal Microbiota Transplantation in Long-Standing Radiation Colitis.Case reports in gastrointestinal medicine · 2019Article
- TLR4 Agonist Monophosphoryl Lipid A Alleviated Radiation-Induced Intestinal Injury.Journal of immunology research · 2019Article
- Protective effect of polydatin on radiation-induced injury of intestinal epithelial and endothelial cells.Bioscience reports · 2018Article
- Adjunctive Treatments for the Prevention of Chemotherapy- and Radiotherapy-Induced Mucositis.Integrative cancer therapies · 2018Article
- BCN057 induces intestinal stem cell repair and mitigates radiation-induced intestinal injury.Stem cell research & therapy · 2018Article
- Antioxidant Supplementation: A Linchpin in Radiation-Induced Enteritis.Technology in cancer research & treatment · 2017Article
- The efficacy of human placenta-derived mesenchymal stem cells on radiation enteropathy along with proteomic biomarkers predicting a favorable response.Stem cell research & therapy · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiation colitis, an insidious, progressive disease of increasing frequency, develops 6 mo to 5 years after regional radiotherapy for malignancy, owing to the deleterious effects of the latter on the colon and the small intestine. When dealing with radiation colitis and its complications, the most conservative modality should be employed because the areas of intestinal injury do not tend to heal. Acute radiation colitis is mostly self-limited, and usually, only supportive management is required. Chronic radiation colitis, a poorly predictable progressive disease, is considered as a precancerous lesion; radiation-associated malignancy has a tendency to be diagnosed at an advanced stage and to bear a dismal prognosis. Therefore, management of chronic radiation colitis remains a major challenge owing to the progressive evolution of the disease, including development of fibrosis, endarteritis, edema, fragility, perforation, partial obstruction, and cancer. Patients are commonly managed conservatively. Surgical intervention is difficult to perform because of the extension of fibrosis and alterations in the gut and mesentery, and should be reserved for intestinal obstruction, perforation, fistulas, and severe bleeding. Owing to the difficulty in managing the complications of acute and chronic radiation colitis, particular attention should be focused onto the prevention strategies. Uncovering the fibrosis mechanisms and the molecular events underlying radiation bowel disease could lead to the introduction of new therapeutic and/or preventive approaches. A variety of novel, mostly experimental, agents have been used mainly as a prophylaxis, and improvements have been made in radiotherapy delivery, including techniques to reduce the amount of exposed intestine in the radiation field, as a critical strategy for prevention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.