Evidence map›Paper›PMID 19109731›Full record

ArticleInternational journal of hematology2009

Cytogenetic analysis in childhood acute lymphoblastic leukemia: experience at a single institution in Korea.

Young Joo Kwon, Jae Wook Lee, Myung Shin Kim, Pil Sang Jang, Nak Gyun Chung, Dae Chul Jeong, Yong Goo Kim, Kyung Ja Han, Soon Ju Lee, Bin Cho and 1 more

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Article in International journal of hematology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Young Joo KwonPediatric Hematology-Oncology Clinic, Center for Specific Organs Cancer, National Cancer Center, Goyang, South Korea.
Jae Wook LeeDepartment of Pediatrics, St Mary's Hospital, The Catholic University of Korea, #62, Yeoudo-dong, Yeongdeungpo-gu, Seoul, 150-713, South Korea.
Myung Shin KimDepartment of Laboratory Medicine, The Catholic University of Korea, Seoul, South Korea.
Pil Sang JangDepartment of Pediatrics, St Mary's Hospital, The Catholic University of Korea, #62, Yeoudo-dong, Yeongdeungpo-gu, Seoul, 150-713, South Korea.
Nak Gyun ChungDepartment of Pediatrics, St Mary's Hospital, The Catholic University of Korea, #62, Yeoudo-dong, Yeongdeungpo-gu, Seoul, 150-713, South Korea.
Dae Chul JeongDepartment of Pediatrics, St Mary's Hospital, The Catholic University of Korea, #62, Yeoudo-dong, Yeongdeungpo-gu, Seoul, 150-713, South Korea.
Yong Goo KimDepartment of Laboratory Medicine, The Catholic University of Korea, Seoul, South Korea.
Kyung Ja HanDepartment of Laboratory Medicine, The Catholic University of Korea, Seoul, South Korea.
Soon Ju LeeDepartment of Pediatrics, St Mary's Hospital, The Catholic University of Korea, #62, Yeoudo-dong, Yeongdeungpo-gu, Seoul, 150-713, South Korea.
Bin ChoDepartment of Pediatrics, St Mary's Hospital, The Catholic University of Korea, #62, Yeoudo-dong, Yeongdeungpo-gu, Seoul, 150-713, South Korea. chobinkr@catholic.ac.kr.
Hack Ki KimDepartment of Pediatrics, St Mary's Hospital, The Catholic University of Korea, #62, Yeoudo-dong, Yeongdeungpo-gu, Seoul, 150-713, South Korea.
Catholic University of Korea · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We evaluated major cytogenetic abnormalities associated with childhood acute lymphoblastic leukemia (ALL) through both fluorescent in situ hybridization and conventional chromosomal analysis for 132 ALL patients diagnosed at St Mary's Hospital in Korea. Chromosome abnormalities have been detected in 92% of patients. Eighteen (14%) patients showed numerical abnormalities only, 50 (38%) patients showed structural abnormalities only, and 53 (40%) patients showed both. The simultaneous trisomies 4, 10 and 17 were observed in 23 (17%) patients. Of the patients with abnormal karyotypes, recurrent structural abnormalities were determined in 103 (78%) cases. t(12;21)(q13;q22) was found in 29 (22%) out of 132 patients, 9p abnormalities in 13 (10%) patients, t(1;19)(q23;p13.3) in 11 (8%) patients, t(9;22)(q34;q11.2) in 11 (8%) patients, and 11q23 abnormalities in 7 (5%) patients. Interestingly, we identified five uncommon translocations such as t(5;12) (q33;p13), t(14;19)(q32;q13.1), t(12;16)(p13;q13), der(1)t(1;12)(p32;p13), and t(5;15)(p15;q11.2). Our study pool is representative of pediatric ALL patients in Korea as it consists of about 20% of patients diagnosed annually in Korea. We believe that the data provided will aid in comparative studies of the treatment outcomes, as well as the type and incidence of chromosomal abnormalities associated with childhood ALL in various Asian nations and Western countries.

Indexed as

Chromosome AberrationsAdolescentChildChild, PreschoolCytogenetic AnalysisFemaleHumansInfantKoreaMalePrecursor Cell Lymphoblastic Leukemia-Lymphoma

Identifiers

PMID19109731
OpenAlexW2036941550

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.