ReviewBlood2009
Chaperoning erythropoiesis.
Review in Blood, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 59 citations in OpenAlex.
- Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia.Blood · 2012Trial
- Oxidative stress modulates heme synthesis and induces peroxiredoxin-2 as a novel cytoprotective response in β-thalassemic erythropoiesis.Haematologica · 2011Trial
- Stage-specific TRIM10 expression regulates erythroid maturation.EMBO reports · 2025Article
- Aging in mice alters regionally enriched striatal astrocytes.Nature communications · 2025Article
- EryDB: A Transcriptomic Profile Database for Erythropoiesis and Erythroid-related Diseases.Genomics, proteomics & bioinformatics · 2025Article
- Erythropoiesis and Gene Expression Analysis in Erythroid Progenitor Cells Derived from Patients with Hemoglobin H/Constant Spring Disease.International journal of molecular sciences · 2024Article
- Targeting Protein Degradation Pathways in Tumors: Focusing on their Role in Hematological Malignancies.Cancers · 2022Review
- Article
- The role of globins in cardiovascular physiology.Physiological reviews · 2022Review
- The Hsp70 chaperone system: distinct roles in erythrocyte formation and maintenance.Haematologica · 2021Review
- Stage Specific Expression Pattern of Alpha-Hemoglobin-Stabilizing-Protein (AHSP) Portrayed in Erythroblast Chronology.Methods and protocols · 2020Article
- Smad2/3-pathway ligand trap luspatercept enhances erythroid differentiation in murine β-thalassaemia by increasing GATA-1 availability.Journal of cellular and molecular medicine · 2020Article
- Heat shock protein 60 regulates yolk sac erythropoiesis in mice.Cell death & disease · 2019Article
- Article
- The intricate role of selenium and selenoproteins in erythropoiesis.Free radical biology & medicine · 2018Review
- Molecular basis of β thalassemia and potential therapeutic targets.Blood cells, molecules & diseases · 2018Review
- Hsp90 chaperones hemoglobin maturation in erythroid and nonerythroid cells.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Quantitative proteomics of plasma vesicles identify novel biomarkers for hemoglobin E/β-thalassemic patients.Blood advances · 2018Article
- Unravelling pathways downstream Sox6 induction in K562 erythroid cells by proteomic analysis.Scientific reports · 2017Article
- Simply red: A novel spectrophotometric erythroid proliferation assay as a tool for erythropoiesis and erythrotoxicity studies.Biotechnology reports (Amsterdam, Netherlands) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Multisubunit complexes containing molecular chaperones regulate protein production, stability, and degradation in virtually every cell type. We are beginning to recognize how generalized and tissue-specific chaperones regulate specialized aspects of erythropoiesis. For example, chaperones intersect with erythropoietin signaling pathways to protect erythroid precursors against apoptosis. Molecular chaperones also participate in hemoglobin synthesis, both directly and indirectly. Current knowledge in these areas only scratches the surface of what is to be learned. Improved understanding of how molecular chaperones regulate erythropoietic development and hemoglobin homeostasis should identify biochemical pathways amenable to pharmacologic manipulation in a variety of red blood cell disorders including thalassemia and other anemias associated with hemoglobin instability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.