ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Relationship of striatal dopamine synthesis capacity to age and cognition.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Reduced dopamine receptors and transporters but not synthesis capacity in normal aging adults: a meta-analysis.Neurobiology of aging · 2017Pooled it
- Striatal presynaptic dopamine in schizophrenia, part II: meta-analysis of [(18)F/(11)C]-DOPA PET studies.Schizophrenia bulletin · 2013Pooled it
- Catecholaminergic modulation of the cost of cognitive control in healthy older adults.PloS one · 2020Trial
- Dose-Dependent Effects of Oral Tyrosine Administration on Plasma Tyrosine Levels and Cognition in Aging.Nutrients · 2017Trial
- Trial
- Trial
- Dopamine Compensates for Amyloid-Induced Default Mode Network Dysfunction to Support Learning.bioRxiv : the preprint server for biology · 2026Article
- Trajectories of late-life depression: insights from molecular imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Alzheimer's Disease Pathologies Affect Dopaminergic Neural Mechanisms of Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Stimulation of CaScience signaling · 2025Article
- A small-molecule screen identifies novel aging modulators by targeting 5-HT/DA signaling pathway.Aging cell · 2025Article
- Monoamine alterations in Alzheimer's disease and their implications in comorbid neuropsychiatric symptoms.GeroScience · 2025Review
- Receptor-Independent Therapies for Forensic Detainees with Schizophrenia-Dementia Comorbidity.International journal of molecular sciences · 2023Article
- Striatal dopamine synthesis and cognitive flexibility differ between hormonal contraceptive users and nonusers.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Article
- A polygenic score indexing a DRD2-related co-expression network is associated with striatal dopamine function.Scientific reports · 2022Article
- Elevated Dopamine Synthesis as a Mechanism of Cognitive Resilience in Aging.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Evidence that ageing yields improvements as well as declines across attention and executive functions.Nature human behaviour · 2022Article
- Horizons in Human Aging Neuroscience: From Normal Neural Aging to Mental (Fr)Agility.Frontiers in human neuroscience · 2022Review
- Age-related impairments on the touchscreen paired associates learning (PAL) task in male rats.Neurobiology of aging · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Past research has demonstrated that performance on frontal lobe-dependent tasks is associated with dopamine system integrity and that various dopamine system deficits occur with aging. The positron emission tomography (PET) radiotracer 6-[(18)F]fluoro-l-m-tyrosine (FMT) is a substrate of the dopamine-synthesizing enzyme, aromatic amino acid decarboxylase (AADC). Studies using 6-[(18)F]fluorodopa (FDOPA) (another AADC substrate) to measure how striatal PET signal and age relate have had inconsistent outcomes. The varying results occur in part from tracer processing that renders FDOPA signal subject to aspects of postrelease metabolism, which may themselves change with aging. In contrast, FMT remains a purer measure of AADC function. We used partial volume-corrected FMT PET scans to measure age-related striatal dopamine synthesis capacity in 21 older (mean, 66.9) and 16 younger (mean, 22.8) healthy adults. We also investigated how striatal FMT signal related to a cognitive measure of frontal lobe function. Older adults showed significantly greater striatal FMT signal than younger adults. Within the older group, FMT signal in dorsal caudate (DCA) and dorsal putamen was greater with age, suggesting compensation for deficits elsewhere in the dopamine system. In younger adults, FMT signal in DCA was lower with age, likely related to ongoing developmental processes. Younger adults who performed worse on tests of frontal lobe function showed greater FMT signal in right DCA, independent of age effects. Our data suggest that higher striatal FMT signal represents nonoptimal dopamine processing. They further support a relationship between striatal dopamine processing and frontal lobe cognitive function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.