Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Prolonged perceptual learning of positional acuity in adult amblyopia: perceptual template retuning dynamics.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 66 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improving Spatial and Temporal Vision in Adult and Juvenile Amblyopia
Does Video Game Play Induce Plasticity in the Visual System of Adults With Amblyopia?
Towards Developing a Perceptual Learning Treatment for Amblyopia
Improving Normal and Amblyopic Vision With Video Games and Perceptual Learning
Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.
- The challenges of amblyopia treatment.Biomedical journal · 2015Pooled it
- Transcranial direct current stimulation enhances recovery of stereopsis in adults with amblyopia.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2013Trial
- Can human amblyopia be treated in adulthood?Strabismus · 2011Trial
- Video-game play induces plasticity in the visual system of adults with amblyopia.PLoS biology · 2011Trial
- Extending Treatment Duration in Perceptual Learning for Amblyopia.Ophthalmology science · 2026Article
- Rethinking perceptual distortions in amblyopia: toward a multi-feature, visual-field-wide perspective.Frontiers in neuroscience · 2026Article
- Playing stereoscopic video games enhances the precision but not the accuracy of depth perception.Scientific reports · 2024Article
- Evaluating Eye Tracking During Dichoptic Video Viewing With Varied Fellow Eye Contrasts in Amblyopia.Investigative ophthalmology & visual science · 2024Article
- PLFest: A New Platform for Accessible, Reproducible, and Open Perceptual Learning Research.Journal of cognitive enhancement : towards the integration of theory and practice · 2024Article
- Visual Cortical Function Changes After Perceptual Learning with Dichoptic Attention Tasks in Adults with Amblyopia: A Case Study Evaluated Using fMRI.Brain sciences · 2024Article
- Perceptual Learning Based on the Lateral Masking Paradigm in Anisometropic Amblyopia With or Without a Patching History.Translational vision science & technology · 2024Article
- Characteristics and predictive factors of visual function improvements after monocular perceptual learning in amblyopia.Heliyon · 2023Article
- Perceptual learning based on a temporal stimulus enhances visual function in adult amblyopic subjects.Scientific reports · 2023Article
- Exogenous attention generalizes location transfer of perceptual learning in adults with amblyopia.iScience · 2022Article
- The effect of initial performance on motion perception improvements is modulated by training method.Attention, perception & psychophysics · 2022Article
- The Effect of Home-Based Dichoptic Therapy on Young Adults with Non-Strabismic Anisometropic Amblyopia on Stereo Acuity.Clinical optometry · 2022Article
- Broad and Long-Lasting Vision Improvements in Youth With Infantile Nystagmus After Home Training With a Perceptual Learning App.Frontiers in neuroscience · 2021Article
- The Clinical Use of Vernier Acuity: Resolution of the Visual Cortex Is More Than Meets the Eye.Frontiers in neuroscience · 2021Review
- Transfer of Perceptual Learning From Local Stereopsis to Global Stereopsis in Adults With Amblyopia: A Preliminary Study.Frontiers in neuroscience · 2021Article
- Rethinking amblyopia 2020.Vision research · 2020Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Amblyopia is a developmental abnormality that results in physiological alterations in the visual cortex and impairs form vision. It is often successfully treated by patching the sound eye in infants and young children, but is generally considered to be untreatable in adults. However, a number of recent studies suggest that repetitive practice of a visual task using the amblyopic eye results in improved performance in both children and adults with amblyopia. These perceptual learning studies have used relatively brief periods of practice; however, clinical studies have shown that the time-constant for successful patching is long. The time-constant for perceptual learning in amblyopia is still unknown. Here we show that the time-constant for perceptual learning depends on the degree of amblyopia. Severe amblyopia requires >50 h (approximately equal to 35,000 trials) to reach plateau, yielding as much as a five-fold improvement in performance at a rate of approximately equal to 1.5%/h. There is significant transfer of learning from the amblyopic to the dominant eye, suggesting that the learning reflects alterations in higher decision stages of processing. Using a reverse correlation technique, we document, for the first time, a dynamic retuning of the amblyopic perceptual decision template and a substantial reduction in internal spatial distortion. These results show that the mature amblyopic brain is surprisingly malleable, and point to more intensive treatment methods for amblyopia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.