ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Four excitatory postsynaptic ionotropic receptors coactivated at the motoneuron-Renshaw cell synapse.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 68 citations in OpenAlex.
- Synaptic imbalance and increased inhibition impair motor function in SMA.Science advances · 2025Article
- Spinal microcircuits go through multiphasic homeostatic compensations in a mouse model of motoneuron degeneration.Cell reports · 2024Article
- Spinal microcircuits go through multiphasic homeostatic compensations in a mouse model of motoneuron degeneration.bioRxiv : the preprint server for biology · 2024Article
- Cholinergic Modulation of Locomotor Circuits in Vertebrates.International journal of molecular sciences · 2022Review
- Synaptic Projections of Motoneurons Within the Spinal Cord.Advances in neurobiology · 2022Article
- Cholinergic feedback to bipolar cells contributes to motion detection in the mouse retina.Cell reports · 2021Article
- αFrontiers in neural circuits · 2021Article
- Motoneuronal Spinal Circuits in Degenerative Motoneuron Disease.Frontiers in molecular neuroscience · 2020Review
- Balanced cholinergic modulation of spinal locomotor circuits via M2 and M3 muscarinic receptors.Scientific reports · 2019Article
- Characterization of Dmrt3-Derived Neurons Suggest a Role within Locomotor Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
- Stoichiometry of the Heteromeric Nicotinic Receptors of the Renshaw Cell.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Recurrent excitation between motoneurones propagates across segments and is purely glutamatergic.PLoS biology · 2018Article
- Spinal Control of Locomotion: Individual Neurons, Their Circuits and Functions.Frontiers in physiology · 2018Review
- Ultrafast and Slow Cholinergic Transmission. Different Involvement of Acetylcholinesterase Molecular Forms.Molecules (Basel, Switzerland) · 2017Review
- Segregation of glutamatergic and cholinergic transmission at the mixed motoneuron Renshaw cell synapse.Scientific reports · 2017Article
- Microcircuit formation following transplantation of mouse embryonic stem cell-derived neurons in peripheral nerve.Journal of neurophysiology · 2017Article
- Article
- The Preparation of Oblique Spinal Cord Slices for Ventral Root Stimulation.Journal of visualized experiments : JoVE · 2016Article
- Synaptic Connectivity between Renshaw Cells and Motoneurons in the Recurrent Inhibitory Circuit of the Spinal Cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renshaw cells (RCs) are spinal interneurons excited by collaterals of the axons of motoneurons (MNs). They respond to a single motoneuronal volley by a surprisingly long (tens of milliseconds) train of action potentials. We have analyzed this synaptic response in spinal cord slices of neonatal mice in light of recent observations suggesting that the MN axons release both acetylcholine and glutamate. We found that the RC synaptic current involves four components of similar amplitudes mediated by two nicotinic receptors (nAChRs, tentatively identified as alpha(7) homomers and alpha(4)beta(2) heteromers) and two glutamate receptors (AMPARs and NMDARs). The decay time constants of the four components cover a wide range: from 3.6 +/- 2.2 ms (alpha(7) nAChRs) to 54.6 +/- 19.5 ms (NMDARs, at -45 mV). The RC discharge can be separated into an initial doublet of high-frequency action potentials followed by later spikes with a variable latency and longer interspike intervals. The initial doublet involves the four ionotropic receptors as well as endogenous voltage-dependent conductances. The late discharge depends on NMDARs, but these receptors must be primed by the initial depolarization. The activation of the NMDARs is prolonged by the fact that their slow deactivation is further slowed by depolarization. The formation of the initial doublet is favored by hyperpolarization, whereas the late discharge is favored by depolarization. This suggests that in physiological conditions the pattern of discharge of the RC in response to a MN input may alternate between a phasic and a tonic response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.