ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Id2 is required for specification of dopaminergic neurons during adult olfactory neurogenesis.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 58 citations in OpenAlex.
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- Fatecode enables cell fate regulator prediction using classification-supervised autoencoder perturbation.Cell reports methods · 2024Article
- Dissecting the spatiotemporal diversity of adult neural stem cells.Molecular systems biology · 2024Article
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- Circuit formation in the adult brain.The European journal of neuroscience · 2022Review
- Id proteins: emerging roles in CNS disease and targets for modifying neural stemcell behavior.Cell and tissue research · 2022Review
- Fusion of single-cell transcriptome and DNA-binding data, for genomic network inference in cortical development.BMC bioinformatics · 2021Article
- Plasma-borne indicators of inflammasome activity in Parkinson's disease patients.NPJ Parkinson's disease · 2021Article
- Neurogenesis From Neural Crest Cells: Molecular Mechanisms in the Formation of Cranial Nerves and Ganglia.Frontiers in cell and developmental biology · 2020Review
- Article
- Dopaminergic Neurones in the Main Olfactory Bulb: An Overview from an Electrophysiological Perspective.Frontiers in neuroanatomy · 2017Review
- Phosphorylation Regulates Id2 Degradation and Mediates the Proliferation of Neural Precursor Cells.Stem cells (Dayton, Ohio) · 2016Article
- Adult Born Olfactory Bulb Dopaminergic Interneurons: Molecular Determinants and Experience-Dependent Plasticity.Frontiers in neuroscience · 2016Review
- The balance of Id3 and E47 determines neural stem/precursor cell differentiation into astrocytes.The EMBO journal · 2015Article
- E Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and Disease.Developmental cell · 2015Review
- Article
- Id2 mediates oligodendrocyte precursor cell maturation arrest and is tumorigenic in a PDGF-rich microenvironment.Cancer research · 2014Article
- Elevated Id2 expression results in precocious neural stem cell depletion and abnormal brain development.Stem cells (Dayton, Ohio) · 2013Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Understanding the biology of adult neural stem cells has important implications for nervous system development and may contribute to our understanding of neurodegenerative disorders and their treatment. We have characterized the process of olfactory neurogenesis in adult mice lacking inhibitor of DNA binding 2(-/-) (Id2(-/-)). We found a diminished olfactory bulb containing reduced numbers of granular and periglomerular neurons with a distinct paucity of dopaminergic periglomerular neurons. While no deficiency of the stem cell compartment was detectable, migrating neuroblasts in Id2(-/-) mutant mice prematurely undergo astroglial differentiation within a disorganized rostral migratory stream. Further, when evaluated in vitro loss of Id2 results in decreased proliferation of neural progenitors and decreased expression of the Hes1 and Ascl1 (Mash1) transcription factors, known mediators of neuronal differentiation. These data support a novel role for sustained Id2 expression in migrating neural progenitors mediating olfactory dopaminergic neuronal differentiation in adult animals.
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Registered trials
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