Evidence map›Paper›PMID 19109488›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008

Control of motoneuron survival by angiogenin.

Dairín Kieran, Jordi Sebastia, Matthew J Greenway, Matthew A King, Dervla Connaughton, Caoimhin G Concannon, Beau Fenner, Orla Hardiman, Jochen H M Prehn

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 106 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 1 synthesis or guideline pooled it, 184 citations in OpenAlex.

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  14. Therapeutic targeting of ALS pathways: Refocusing an incomplete picture.Annals of clinical and translational neurology · 2023
    Review
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46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Dairín KieranDepartment of Physiology and Medical Physics and Royal College of Surgeons in Ireland Neuroscience Research Centre, RCSI, Dublin 2, Ireland.
Jordi Sebastia
Matthew J Greenway
Matthew A King
Dervla Connaughton
Caoimhin G Concannon
Beau Fenner
Orla Hardiman
Jochen H M Prehn
Royal College of Surgeons in Ireland · IEBeaumont Hospital · IEChildren's Health Ireland at Crumlin · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in the hypoxia-inducible factor angiogenin (ANG) have been identified in Amyotrophic Lateral Sclerosis (ALS) patients, but the potential role of ANG in ALS pathogenesis was undetermined. Here we show that angiogenin promotes motoneuron survival both in vitro and in vivo. Angiogenin protected cultured motoneurons against excitotoxic injury in a PI-3-kinase/Akt kinase-dependent manner, whereas knock-down of angiogenin potentiated excitotoxic motoneuron death. Expression of wild-type ANG protected against endoplasmic reticulum (ER) stress-induced and trophic-factor-withdrawal-induced cell death in vitro, whereas the ALS-associated ANG mutant K40I exerted no protective activity and failed to activate Akt-1. In SOD1(G93A) mice angiogenin delivery increased lifespan and motoneuron survival, restored the disease-associated decrease in Akt-1 survival signaling, and reversed a pathophysiological increase in ICAM-1 expression. Our data demonstrate that angiogenin is a key factor in the control of motoneuron survival.

Indexed as

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAmyotrophic Lateral SclerosisAndrostadienesAnimalsCells, CulturedCell SurvivalDisease Models, AnimalEmbryo, MammalianEnzyme InhibitorsExcitatory Amino Acid AgonistsFemaleGene ExpressionGene Expression RegulationInsulin-Like Growth Factor IIntercellular Adhesion Molecule-1Malealpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAndrostadienesangiogeninEnzyme InhibitorsExcitatory Amino Acid AgonistsInsulin-Like Growth Factor IIntercellular Adhesion Molecule-1Neuroprotective AgentsOncogene Protein v-aktRibonuclease, PancreaticRNA, Small InterferingSOD1 G93A proteinSuperoxide DismutaseTunicamycinWortmannin

Identifiers

PMID19109488
PMCPMC6671464
OpenAlexW2134135259

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.