ArticleJournal of clinical microbiology2009
Clinical predictive value of real-time PCR quantification of human cytomegalovirus DNA in amniotic fluid samples.
Article in Journal of clinical microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Intrauterine therapy of cytomegalovirus infection with valganciclovir: review of the literature.Medical microbiology and immunology · 2017Pooled it
- Prenatal ultrasound findings associated with intrauterine CMV infection: a multicenter retrospective analysis of clinical and sonographic features.BMC pregnancy and childbirth · 2026Observational
- PCR-based detection of cytomegalovirus in neonates and children, with emphasis on congenital and neonatal-screening cohorts: A systematic review and meta-analysis.SAGE open medicine · 2026Review
- Prenatal Screening for CMV Primary Infection: A Cost-Utility Model.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Brain Metabolite Differences in Fetuses With Cytomegalovirus Infection: A Magnetic Resonance Spectroscopy Study.Journal of magnetic resonance imaging : JMRI · 2025Article
- Is a Higher Amniotic Fluid Viral Load Associated with a Greater Risk of Fetal Injury in Congenital Cytomegalovirus Infection-A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Performance of Zika Assays in the Context of Toxoplasma gondii, Parvovirus B19, Rubella Virus, and Cytomegalovirus (TORCH) Diagnostic Assays.Clinical microbiology reviews · 2019Review
- Cytomegalovirus infection in pregnancy.Birth defects research · 2017Review
- Study of Soluble HLA-G in Congenital Human Cytomegalovirus Infection.Journal of immunology research · 2016Article
- Identification of Symptomatic Fetuses Infected with Cytomegalovirus Using Amniotic Fluid Peptide Biomarkers.PLoS pathogens · 2016Article
- Cytomegalovirus, Toxoplasma gondii and Rubella Vertical Transmission Rates According to Mid-trimester Amniocentesis: A Retrospective Study.International journal of preventive medicine · 2015Article
- Article
- The "silent" global burden of congenital cytomegalovirus.Clinical microbiology reviews · 2013Review
- Viral invasion of the amniotic cavity (VIAC) in the midtrimester of pregnancy.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2012Article
- Overview of the diagnosis of cytomegalovirus infection.Infectious disorders drug targets · 2011Article
- Screening for cytomegalovirus during pregnancy.Infectious diseases in obstetrics and gynecology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to evaluate the diagnostic reliability and prognostic significance of the quantification of cytomegalovirus (CMV) DNA in amniotic fluid (AF). We retrospectively reviewed the results for 282 amniotic fluid samples that had been tested for CMV by a quantitative real-time PCR. We observed three cases in which no CMV genomes were detected in the AF but in which the children were nevertheless congenitally infected. Hence, we conclude that a negative result by PCR for CMV in AF cannot rule out the possibility of congenital infection. No false-positive PCR results were observed. A correlation between the CMV viral load in AF and the fetal and neonatal outcomes could not be demonstrated in our study. Instead, a correlation was found between the CMV viral load and the gestational age at the time of amniocentesis.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.