ArticleJournal of clinical microbiology2009
Optical fingerprinting in bacterial epidemiology: Raman spectroscopy as a real-time typing method.
Article in Journal of clinical microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 109 citations in OpenAlex.
- Label-Free Differentiation of Antimicrobial Resistance Groups Using Raman Spectroscopy.Analytical chemistry · 2026Article
- Accelerated detection of carbapenem resistance in Klebsiella pneumoniae via single-cell Raman spectroscopy.World journal of microbiology & biotechnology · 2025Article
- Enhancing photosynthetic efficiency in Phalaenopsis amabilis through bioreactor innovations.BMC plant biology · 2024Article
- Review
- Illuminating the Tiny World: A Navigation Guide for Proper Raman Studies on Microorganisms.Molecules (Basel, Switzerland) · 2024Review
- Opportunities in optical and electrical single-cell technologies to study microbial ecosystems.Frontiers in microbiology · 2023Review
- Optical Methods for Label-Free Detection of Bacteria.Biosensors · 2022Review
- Comparison of Different Label-Free Raman Spectroscopy Approaches for the Discrimination of Clinical MRSA and MSSA Isolates.Microbiology spectrum · 2022Article
- Detection of multi-resistant clinical strains of E. coli with Raman spectroscopy.Analytical and bioanalytical chemistry · 2022Article
- Raman Spectroscopy Technique: A Non-Invasive Tool in Celiac Disease Diagnosis.Diagnostics (Basel, Switzerland) · 2021Article
- Biochemical characterization of pathogenic bacterial species using Raman spectroscopy and discrimination model based on selected spectral features.Lasers in medical science · 2021Article
- Advances in Optical Detection of Human-Associated Pathogenic Bacteria.Molecules (Basel, Switzerland) · 2020Review
- Clinical impact of endemic NDM-producing Klebsiella pneumoniae in intensive care units of the national referral hospital in Jakarta, Indonesia.Antimicrobial resistance and infection control · 2020Observational
- Rapid and label-free detection of COVID-19 using coherent anti-Stokes Raman scattering microscopy.MRS communications · 2020Article
- Reducing transmission of methicillin-resistantInfection prevention in practice · 2019Article
- Fourier transform infrared spectroscopy: unlocking fundamentals and prospects for bacterial strain typing.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Review
- Microfluidic Cultivation and Laser Tweezers Raman Spectroscopy ofSensors (Basel, Switzerland) · 2018Article
- Endemic carbapenem-nonsusceptibleAntimicrobial resistance and infection control · 2018Article
- A study on identification of bacteria in environmental samples using single-cell Raman spectroscopy: feasibility and reference libraries.Environmental science and pollution research international · 2016Article
- Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hospital-acquired infections (HAI) increase morbidity and mortality and constitute a high financial burden on health care systems. An effective weapon against HAI is early detection of potential outbreaks and sources of contamination. Such monitoring requires microbial typing with sufficient reproducibility and discriminatory power. Here, a microbial-typing method is presented, based on Raman spectroscopy. This technique provides strain-specific optical fingerprints in a few minutes instead of several hours to days, as is the case with genotyping methods. Although the method is generally applicable, we used 118 Staphylococcus aureus isolates to illustrate that the discriminatory power matches that of established genotyping techniques (numerical index of diversity [D]=0.989) and that concordance with the gold standard (pulsed-field gel electrophoresis) is high (95%). The Raman clustering of isolates was reproducible to the strain level for five independent cultures, despite the various culture times from 18 h to 24 h. Furthermore, this technique was able to classify stored (-80 degrees C) and recent isolates of a methicillin-resistant Staphylococcus aureus-colonized individual during surveillance studies and did so days earlier than established genotyping techniques did. Its high throughput and ease of use make it suitable for use in routine diagnostic laboratory settings. This will set the stage for continuous, automated, real-time epidemiological monitoring of bacterial infections in a hospital, which can then be followed by timely corrective action by infection prevention teams.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.