ArticleProceedings of the National Academy of Sciences of the United States of America2009
A role for the host coatomer and KDEL receptor in early vaccinia biogenesis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 30 citations in OpenAlex.
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- The Diffusion Model of Intra-Golgi Transport Has Limited Power.International journal of molecular sciences · 2023Article
- KDEL Receptors: Pathophysiological Functions, Therapeutic Options, and Biotechnological Opportunities.Biomedicines · 2022Review
- Cytoplasmic tail determines the membrane trafficking and localization of SARS-CoV-2 spike protein.Frontiers in molecular biosciences · 2022Review
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- DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling.Cell research · 2018Article
- Identification of Secreted Proteins Involved in Nonspecific dsRNA-Mediated Lutzomyia longipalpis LL5 Cell Antiviral Response.Viruses · 2018Article
- Cellular interactome analysis of vaccinia virus K7 protein identifies three transport machineries as binding partners for K7.Virus genes · 2017Article
- Influenza infection modulates vesicular trafficking and induces Golgi complex disruption.Virusdisease · 2016Article
- A KDEL Retrieval System for ER-Golgi Transport of Japanese Encephalitis Viral Particles.Viruses · 2016Article
- A role for retromer in hepatitis C virus replication.Cellular and molecular life sciences : CMLS · 2016Article
- Biogenesis of endosome-derived transport carriers.Cellular and molecular life sciences : CMLS · 2015Review
- Hepatitis C virus NS5A hijacks ARFGAP1 to maintain a phosphatidylinositol 4-phosphate-enriched microenvironment.Journal of virology · 2014Article
- Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Genome-wide RNAi screen identifies novel host proteins required for alphavirus entry.PLoS pathogens · 2013Article
- Role of Coatomer Protein I in Virus Replication.Journal of virology & antiviral research · 2012Article
- Orf virus interferes with MHC class I surface expression by targeting vesicular transport and Golgi.BMC veterinary research · 2012Article
- Irradiation-induced protein inactivation reveals Golgi enzyme cycling to cell periphery.Journal of cell science · 2012Article
- ARF1 and GBF1 generate a PI4P-enriched environment supportive of hepatitis C virus replication.PloS one · 2012Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
Abstract
Members of the poxvirus family have been investigated for their applications as vaccines and expression vectors and, more recently, because of concern for their potential as biological weapons. Vaccinia virus, the prototypic member, evolves through multiple forms during its replication. Here, we show a surprising way by which vaccinia hijacks coatomer for early viral biogenesis. Whereas coatomer forms COPI vesicles in the host early secretory system, vaccinia formation bypasses this role of coatomer, but instead, depends on coatomer interacting with the host KDEL receptor. To gain insight into the viral roles of these two host proteins, we have detected them on the earliest recognized viral forms. These findings not only suggest insights into early vaccinia biogenesis but also reveal an alternate mechanism by which coatomer acts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.