ArticlePlant physiology2009
Reactive oxygen species production by potato tuber mitochondria is modulated by mitochondrially bound hexokinase activity.
Article in Plant physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- Characterization of black oat root exudates in the presence of interspecific weed species and intraspecific neighbors, and their effects on root traits.Frontiers in plant science · 2026Article
- Genomic Analysis of Hexokinase Genes in Foxtail Millet (International journal of molecular sciences · 2025Article
- Coupling of GABA Metabolism to Mitochondrial Glucose Phosphorylation.Neurochemical research · 2022Article
- Try or Die: Dynamics of Plant Respiration and How to Survive Low Oxygen Conditions.Plants (Basel, Switzerland) · 2022Review
- Proteomics analysis reveals that foreignGM crops & food · 2021Article
- Effects of Salicylic Acid on the Metabolism of Mitochondrial Reactive Oxygen Species in Plants.Biomolecules · 2020Review
- Genome-Wide Identification and Characterization of Hexokinase Genes in Moso Bamboo (Frontiers in plant science · 2020Article
- Salicylic acid-induced ROS production by mitochondrial electron transport chain depends on the activity of mitochondrial hexokinases in tomato (Solanum lycopersicum L.).Journal of plant research · 2019Article
- Biochemical properties and subcellular localization of six members of the HXK family in maize and its metabolic contribution to embryo germination.BMC plant biology · 2019Article
- Mitochondria-Bound Hexokinase (mt-HK) Activity Differ in Cortical and Hypothalamic Synaptosomes: Differential Role of mt-HK in HMolecular neurobiology · 2018Article
- Cooperative interaction of antimicrobial peptides with the interrelated immune pathways in plants.Molecular plant pathology · 2016Review
- Mathematical modeling reveals that metabolic feedback regulation of SnRK1 and hexokinase is sufficient to control sugar homeostasis from energy depletion to full recovery.Frontiers in plant science · 2014Article
- Altered sucrose synthase and invertase expression affects the local and systemic sugar metabolism of nematode-infected Arabidopsis thaliana plants.Journal of experimental botany · 2014Article
- Article
- Article
- Article
- Mitochondrial ferritin is a functional iron-storage protein in cucumber (Cucumis sativus) roots.Frontiers in plant science · 2013Article
- Effects of drought on gene expression in maize reproductive and leaf meristem tissue revealed by RNA-Seq.Plant physiology · 2012Article
- Protein Kinase Signaling at the Crossroads of Myocyte Life and Death in Ischemic Heart Disease.Drug discovery today. Therapeutic strategies · 2012Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Potato tuber (Solanum tuberosum) mitochondria (PTM) have a mitochondrially bound hexokinase (HK) activity that exhibits a pronounced sensitivity to ADP inhibition. Here we investigated the role of mitochondrial HK activity in PTM reactive oxygen species generation. Mitochondrial HK has a 10-fold higher affinity for glucose (Glc) than for fructose (KMGlc=140 microM versus KMFrc=1,375 microM). Activation of PTM respiration by succinate led to an increase in hydrogen peroxide (H2O2) release that was abrogated by mitochondrial HK activation. Mitochondrial HK activity caused a decrease in the mitochondrial membrane potential and an increase in oxygen consumption by PTM. Inhibition of Glc phosphorylation by mannoheptulose or GlcNAc induced a rapid increase in H2O2 release. The blockage of H2O2 release sustained by Glc was reverted by oligomycin and atractyloside, indicating that ADP recycles through the adenine nucleotide translocator and F0F1ATP synthase is operative during the mitochondrial HK reaction. Inhibition of mitochondrial HK activity by 60% to 70% caused an increase of 50% in the maximal rate of H2O2 release. Inhibition in H2O2 release by mitochondrial HK activity was comparable to, or even more potent, than that observed for StUCP (S. tuberosum uncoupling protein) activity. The inhibition of H2O2 release in PTM was two orders of magnitude more selective for the ADP produced from the mitochondrial HK reaction than for that derived from soluble yeast (Saccharomyces cerevisiae) HK. Modulation of H2O2 release and oxygen consumption by Glc and mitochondrial HK inhibitors in potato tuber slices shows that hexoses and mitochondrial HK may act as a potent preventive antioxidant mechanism in potato tubers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.