ArticleMolecular biology and evolution2009
Spontaneous mutational and standing genetic (co)variation at dinucleotide microsatellites in Caenorhabditis briggsae and Caenorhabditis elegans.
Article in Molecular biology and evolution, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- T2T genomes ofGenome research · 2026Article
- Heat tolerance and genetic adaptations in Caenorhabditis briggsae: insights from comparative studies with Caenorhabditis elegans.Genetics · 2025Article
- Evolution of the Mutational Process under Relaxed Selection in Caenorhabditis elegans.Molecular biology and evolution · 2019Article
- Article
- Darwinism for the Genomic Age: Connecting Mutation to Diversification.Frontiers in genetics · 2017Article
- Insertion sequence-caused large-scale rearrangements in the genome of Escherichia coli.Nucleic acids research · 2016Article
- Mutation Is a Sufficient and Robust Predictor of Genetic Variation for Mitotic Spindle Traits in Caenorhabditis elegans.Genetics · 2016Article
- Article
- Reproductive Mode and the Evolution of Genome Size and Structure in Caenorhabditis Nematodes.PLoS genetics · 2015Article
- The red death meets the abdominal bristle: polygenic mutation for susceptibility to a bacterial pathogen in Caenorhabditis elegans.Evolution; international journal of organic evolution · 2015Article
- Temperature, stress and spontaneous mutation in Caenorhabditis briggsae and Caenorhabditis elegans.Biology letters · 2013Article
- Genomic background and generation time influence deleterious mutation rates in Daphnia.Genetics · 2013Article
- Article
- Variation in base-substitution mutation in experimental and natural lineages of Caenorhabditis nematodes.Genome biology and evolution · 2012Article
- Natural variation in life history and aging phenotypes is associated with mitochondrial DNA deletion frequency in Caenorhabditis briggsae.BMC evolutionary biology · 2011Article
- Rapid decline in fitness of mutation accumulation lines of gonochoristic (outcrossing) Caenorhabditis nematodes.Evolution; international journal of organic evolution · 2010Article
- Natural selection shapes nucleotide polymorphism across the genome of the nematode Caenorhabditis briggsae.Genome research · 2010Article
- Bias and evolution of the mutationally accessible phenotypic space in a developmental system.PLoS genetics · 2010Article
- Mutational dynamics of microsatellites.Molecular biotechnology · 2010Review
- High rate of large deletions in Caenorhabditis briggsae mitochondrial genome mutation processes.Genome biology and evolution · 2009Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Understanding the evolutionary processes responsible for shaping genetic variation within and between species requires separating the effects of mutation and selection. Differences between the patterns of genetic variation observed in nature and when mutations are allowed to accumulate in the relative absence of selection can reveal biases imposed by selection. We characterize the genetic variation at dinucleotide microsatellite repeats in four sets of 250-generation mutation accumulation (MA) lines, two in the species Caenorhabditis briggsae and two in Caenorhabditis elegans, and compare the mutational variation with the standing variation in those species. We also compare the mutational properties of microsatellites with the cumulative effects of mutations on fitness in the same lines. Integrated over the whole genome, we infer that the mutation rate of C. briggsae is about twice that of C. elegans, consistent with the cumulative mutational effects on fitness. The mutational spectrum (ratio of insertions to deletions) differs between repeat types and, in some cases, between species. The per-locus mutation rate is significantly positively correlated with the standing genetic variation at the same locus in both species, providing justification for the common practice of using the standing genetic variance as a surrogate for the mutation rate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.