ArticleHaematologica2009
STAT6-mediated suppression of erythropoiesis in an experimental model of malarial anemia.
Article in Haematologica, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 37 citations in OpenAlex.
- Role of STAT1 in modulating the host immune response toMicrobiology spectrum · 2026Article
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- Association Between Blood PLT and RBC Related Indices and Disease Activity in Patients with Rheumatoid Arthritis.International journal of general medicine · 2022Article
- Challenges in forming inferences from limited data: a case study of malaria parasite maturation.Journal of the Royal Society, Interface · 2021Article
- Development of a model for anemia of inflammation that is relevant to critical care.Intensive care medicine experimental · 2019Article
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- Integrative analysis associates monocytes with insufficient erythropoiesis during acute Plasmodium cynomolgi malaria in rhesus macaques.Malaria journal · 2017Article
- Effect of Promoter Polymorphisms on Cytokine Concentration in Preterm Breast Milk and Subsequent Infant Outcomes.Journal of human lactation : official journal of International Lactation Consultant Association · 2016Article
- A STAT6 Intronic Single-Nucleotide Polymorphism is Associated with Clinical Malaria in Ghanaian Children.Genetics & epigenetics · 2016Article
- Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels.BMC immunology · 2013Article
- Pathogenesis of malaria in tissues and blood.Mediterranean journal of hematology and infectious diseases · 2012Article
- Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Article
- Genome wide linkage study, using a 250K SNP map, of Plasmodium falciparum infection and mild malaria attack in a Senegalese population.PloS one · 2010Article
- Mapping of Char10, a novel malaria susceptibility locus on mouse chromosome 9.Genes and immunity · 2010Article
- Animal models of anemia of inflammation.Seminars in hematology · 2009Review
- Malarial anemia and STAT6.Haematologica · 2009Review
- Malaria, erythrocytic infection, and anemia.Hematology. American Society of Hematology. Education Program · 2009Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe contribution of pro-inflammatory cytokines to the pathogenesis of malarial anemia has been studied extensively but the roles of Th2 cytokines remain unknown. Here, we investigated the role of signal transducer and activator of transcription (STAT)6-mediated responses in erythropoietic suppression during acute malaria infection in mice. DESIGN AND
methodsNaïve and/or erythropoietin-treated wild-type and STAT6(-/-) mice were infected with Plasmodium chabaudi AS (P. chabaudi), and the effects parasitemia, hematologic parameters, erythropoietin receptor, TER119, and CD71 expression, in vitro erythropoietin-stimulated proliferation of splenic erythroid precursors, and serum cytokine levels were analyzed. To explore the role of interleukin-4 in STAT6-dependent erythropoietic suppression, mice were treated in vivo with a monoclonal antibody to interleukin-4 and the effects on parasitemia, hematologic parameters, and cytokine levels were analyzed.
resultsInfected STAT6(-/-) mice developed enhanced reticulocytosis compared to wild-type mice despite higher parasitemia and a similar course of anemia. Enhanced reticulocytosis in infected STAT6(-/-) mice was associated with an increased frequency of late-stage erythroblasts, fewer leukocytes expressing CD71, and increased erythropoietin-stimulated proliferation of splenocytes compared to infected wild-type mice. Interleukin-4-depleted wild-type mice had increased levels of parasitemia and a course of reticulocytosis similar to responses observed in infected STAT6(-/-) mice. Determination of serum cytokine levels in STAT6(-/-) and wild-type mice depleted of interleukin-4 by treatment with mAb revealed significantly lower levels of interferon-gamma compared to control wild-type mice during infection.
conclusionsTogether, these findings provide evidence for a STAT6-dependent mechanism in mediating erythropoietic suppression during acute blood-stage malaria and indicate a role for interleukin-4 and possibly interferon-gammain STAT6-induced erythropoietic suppression.
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