ArticleJournal of immunology (Baltimore, Md. : 1950)2009
TCR mu recombination and transcription relative to the conventional TCR during postnatal development in opossums.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Deciphering the origins of guanylate-binding proteins in mammals (Monotreme, Marsupials and Placentals).BMC biology · 2025Article
- Comparative genomics of the T cell receptor μ locus in marsupials and monotremes.Immunogenetics · 2023Article
- Identification of regenerative processes in neonatal spinal cord injury in the opossum (Monodelphis domestica): A transcriptomic study.The Journal of comparative neurology · 2021Article
- Molecular, Cellular and Functional Analysis of TRγ Chain along the European Sea BassInternational journal of molecular sciences · 2021Article
- TR Locus Annotation and Characteristics ofFrontiers in immunology · 2021Article
- Opossum Mammary Maturation as It Relates to Immune Cell Infiltration and Nutritional Gene Transcription.Integrative organismal biology (Oxford, England) · 2020Article
- Opossum milk IgG is from maternal circulation and timing of transfer correlates with neonatal immune development.Reproduction, fertility, and development · 2019Article
- Functional Conservation of a Developmental Switch in Mammals since the Jurassic Age.Molecular biology and evolution · 2019Article
- On the prenatal initiation of T cell development in the opossum Monodelphis domestica.Journal of anatomy · 2017Article
- Evolution of innate-like T cells and their selection by MHC class I-like molecules.Immunogenetics · 2016Review
- Genome complexity in the coelacanth is reflected in its adaptive immune system.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2014Article
- Article
- A VpreB3 homologue in a marsupial, the gray short-tailed opossum, Monodelphis domestica.Immunogenetics · 2012Article
- Early postnatal B cell ontogeny and antibody repertoire maturation in the opossum, Monodelphis domestica.PloS one · 2012Article
- Platypus TCRμ provides insight into the origins and evolution of a uniquely mammalian TCR locus.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Transcriptomic analysis supports similar functional roles for the two thymuses of the tammar wallaby.BMC genomics · 2011Article
- Immunome database for marsupials and monotremes.BMC immunology · 2011Article
- Those other mammals: the immunoglobulins and T cell receptors of marsupials and monotremes.Seminars in immunology · 2010Review
- On the genomics of immunoglobulins in the gray, short-tailed opossum Monodelphis domestica.Immunogenetics · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Marsupials are a distinct lineage of mammals notable for giving birth to highly altricial (relatively less developed) young. The recent discovery of a unique TCR chain in marsupials, TCRmu, raises questions about its possible role in early development. Here we compare the timing of V(D)J recombination and appearance of TCRmu transcripts relative to the conventional TCRalpha, beta, gamma, and delta mRNA during postnatal development in the opossum. There are two TCRmu transcript isoforms, TCRmu1.0 and TCRmu2.0. TCRmu1.0, which uses prejoined V(D)J segments, is detectable as early as day 1, when the thymus is primarily undifferentiated epithelium. The other isoform, TCRmu2.0, which requires V(D)J recombination and contains an unusual double V configuration, is not detectable until day 13 when the thymus is histologically mature. Surprisingly, we were able to detect TCRalpha, beta, and delta mRNA transcribed from loci that had completed V(D)J recombination as early as day 1 as well. At this early age there is apparent evidence for preference in the V segments used in the TCRalpha and beta genes. In the case of Valpha this preference appears to be associated with position in the TCRalpha/delta locus. In Vbeta, however, preference may be due to the use of microhomology in the V, D, and J segments. Mature TCRgamma transcripts were not detected until day 8, suggesting that, in contrast to eutherian mammals, in the opossum alphabeta T cell development precedes gammadelta T cell development. The results support that there may be differences in T cell subset development between marsupials and placental mammals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.