ArticleJournal of the American Society for Mass Spectrometry2009
What is the structure of b(2) ions generated from doubly protonated tryptic peptides?
Article in Journal of the American Society for Mass Spectrometry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 68 citations in OpenAlex.
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- Isomeric Differentiation and Acidic Metabolite Identification by Piperidine-Based Tagging, LC-MS/MS, and Understanding of the Dissociation Chemistries.Analytical chemistry · 2020Article
- Spectroscopic Evidence for Lactam Formation in Terminal Ornithine bJournal of the American Society for Mass Spectrometry · 2019Article
- Fragmentation of Multi-charged Derivatized Lysine Using Nanospray CID Tandem Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2019Article
- Participation of C-H Protons in the Dissociation of a Proton Deficient Dipeptide.Journal of the American Society for Mass Spectrometry · 2017Article
- Proton Mobility in b₂ Ion Formation and Fragmentation Reactions of Histidine-Containing Peptides.Journal of the American Society for Mass Spectrometry · 2016Article
- Formation of a(1) ions directly from oxazolone b(2) ions: an energy-resolved and computational study.Journal of the American Society for Mass Spectrometry · 2015Article
- Loss of internal backbone carbonyls: additional evidence for sequence-scrambling in collision-induced dissociation of y-type ions.Journal of the American Society for Mass Spectrometry · 2014Article
- Article
- Evidence for sequence scrambling in collision-induced dissociation of y-type fragment ions.Journal of the American Society for Mass Spectrometry · 2013Article
- Protonated dipeptide losses from b(5) and b(4) ions of side chain hydroxyl group containing pentapeptides.Journal of the American Society for Mass Spectrometry · 2013Article
- Non-direct sequence ions in the tandem mass spectrometry of protonated peptide amides--an energy-resolved study.Journal of the American Society for Mass Spectrometry · 2013Article
- Influence of N-terminal residue composition on the structure of proline-containing b2+ ions.The journal of physical chemistry. A · 2013Article
- A comparison of the effects of amide and acid groups at the C-terminus on the collision-induced dissociation of deprotonated peptides.Journal of the American Society for Mass Spectrometry · 2012Article
- Carbonyl charge solvation patterns may relate to fragmentation classes in collision-activated dissociation.Journal of the American Society for Mass Spectrometry · 2012Article
- Conformation-specific spectroscopy of peptide fragment ions in a low-temperature ion trap.Journal of the American Society for Mass Spectrometry · 2012Article
- Structural influences on preferential oxazolone versus diketopiperazine b(2+) ion formation for histidine analogue-containing peptides.The journal of physical chemistry. A · 2012Article
- Relative stability of peptide sequence ions generated by tandem mass spectrometry.Journal of the American Society for Mass Spectrometry · 2012Article
- Rearrangement pathways of the a (4) ion of protonated YGGFL characterized by IR spectroscopy and modeling.Journal of the American Society for Mass Spectrometry · 2012Article
- Dissociation chemistry of hydrogen-deficient radical peptide anions.Journal of the American Society for Mass Spectrometry · 2012Article
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A recent statistical study (Savitski, M. M.; Falth, M.; Eva Fung, Y. M.; Adams, C. M.; Zubarev, R. A. J. Am. Soc. for Mass Spectrom.doi: 10.1016/j.jasms.2008.08.003) of a large spectral database indicated that the product ion spectra of doubly protonated tryptic peptides fall into two distinct classes. The main factor distinguishing the two classes is the relative abundance of the y(N-2) fragment: for Class I spectra y(N-2) is the most abundant y fragment while for Class II other y ions dominate the corresponding spectra. To explain the dominance of y(N-2) for Class I spectra formation of a nontraditional b(2) ion with a diketopiperazine (6-membered cyclic peptide) rather than an oxazolone structure was proposed. Here we present evidence from tandem mass spectrometry, hydrogen/deuterium exchange, and density functional calculations that do not support this proposal. Namely, that CID of doubly protonated YIGSR, YGGFLR, and YIYGSFK produce Class I product ion spectra, yet the b(2) fragment is shown to have the traditional oxazolone structure.
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