ArticleFertility and sterility2009
Nuclear maturation and structural components of nonhuman primate cumulus-oocyte complexes during in vivo and in vitro maturation.
Article in Fertility and sterility, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Granulosa Cells Improved Mare Oocyte Cytoplasmic Maturation by Providing Collagens.Frontiers in cell and developmental biology · 2022Article
- Dietary sugar in healthy female primates perturbs oocyte maturation and in vitro preimplantation embryo development.Endocrinology · 2014Article
- Rhesus monkey cumulus cells revert to a mural granulosa cell state after an ovulatory stimulus.Endocrinology · 2012Article
- Extensive effects of in vitro oocyte maturation on rhesus monkey cumulus cell transcriptome.American journal of physiology. Endocrinology and metabolism · 2011Article
- Primate model of metaphase I oocyte in vitro maturation and the effects of a novel glutathione donor on maturation, fertilization, and blastocyst development.Fertility and sterility · 2011Article
- Dynamics of intra-follicular glucose during luteinization of macaque ovarian follicles.Molecular and cellular endocrinology · 2011Article
- Role for cumulus cell-produced EGF-like ligands during primate oocyte maturation in vitro.American journal of physiology. Endocrinology and metabolism · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo compare cumulus cell structure and timing of oocyte maturation of in vitro-matured (IVM) and in vivo-matured (VVM) nonhuman primate oocytes.
designIn vivo maturation and in vitro maturation of oocytes.
settingAnimal cell culture laboratory. ANIMAL(S): Forty-eight female rhesus macaques. INTERVENTION(S): Fifteen animals were administered FSH, and aspirated oocytes were cultured in vitro for 0, 3, 6, 12, or 24 hours (IVM). Thirty-three animals were administered FSH and hCG, and oocytes were collected 3, 6, 12, or 28-30 hours after hCG (VVM). MAIN OUTCOME MEASURE(S): Nuclear maturation and microtubule scores of oocytes and actin and tubulin transzonal processes of cumulus cells. Embryo development was observed for VVM oocytes. RESULT(S): The rate of nuclear maturation was faster for IVM oocytes compared with VVM oocytes. Actin transzonal processes decreased 0-12 hours after hCG administration for VVM oocytes. Tubulin transzonal processes of IVM and VVM oocytes decreased from 0 to 24 hours and from 0 to 3 hours, respectively. Embryo development improved as VVM time increased. CONCLUSION(S): Nuclear maturation and remodeling of cumulus-oocyte complex structural components associated with in vitro maturation do not parallel those of oocyte maturation in vivo, indicating that in vitro culture conditions continue to be suboptimal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.