ArticleJournal of child and adolescent psychopharmacology2008
Neurochemical alterations in adolescent bipolar depression: a proton magnetic resonance spectroscopy pilot study of the prefrontal cortex.
Article in Journal of child and adolescent psychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- The underlying neurobiology of key functional domains in young people with mood and anxiety disorders: a systematic review.BMC psychiatry · 2016Pooled it
- Effect of the Putative Lithium Mimetic Ebselen on Brain Myo-Inositol, Sleep, and Emotional Processing in Humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- Effects of fish oil supplementation on prefrontal metabolite concentrations in adolescents with major depressive disorder: a preliminary 1H MRS study.Nutritional neuroscience · 2016Trial
- Neurometabolite effects of response to quetiapine and placebo in adolescents with bipolar depression.Journal of child and adolescent psychopharmacology · 2012Trial
- Neurofunctional Correlates of Response to Quetiapine in Adolescents with Bipolar Depression.Journal of child and adolescent psychopharmacologyTrial
- Neuroimaging insights from Wistar-Kyoto rats under chronic mild stress: morphological and metabolic brain correlates of treatment-resistant depression.Scientific reports · 2026Article
- Differences in biochemical metabolism and cognitive function between bipolar I and bipolar II disorder.BMC psychiatry · 2026Observational
- A Magnetic Resonance Spectroscopy Study on Polarity Subphenotypes in Bipolar Disorder.Diagnostics (Basel, Switzerland) · 2024Article
- Exploration of neurometabolic alterations in adolescent patients with bipolar depression and non-suicidal self-injury based on proton magnetic resonance spectroscopy.Frontiers in psychiatry · 2024Article
- Neurocognitive Correlates of Cerebellar Volumetric Alterations in Youth with Pediatric Bipolar Spectrum Disorders and Bipolar Offspring.Current neuropharmacology · 2023Article
- Exploring neurometabolic alterations in bipolar disorder with suicidal ideation based on proton magnetic resonance spectroscopy and machine learning technology.Frontiers in neuroscience · 2022Article
- Glutamatergic Correlates of Bipolar Symptoms in Adolescents.Journal of child and adolescent psychopharmacology · 2020Article
- Creatine for the Treatment of Depression.Biomolecules · 2019Review
- Metabolic Changes Associated with a Rat Model of Diabetic Depression Detected by Ex VivoNeural plasticity · 2018Article
- Normal Metabolic Levels in Prefrontal Cortex in Euthymic Bipolar I Patients with and without Suicide Attempts.Neural plasticity · 2015Article
- A review of MR spectroscopy studies of pediatric bipolar disorder.AJNR. American journal of neuroradiology · 2014Review
- Anterior cingulate cortex choline levels in female adolescents with unipolar versus bipolar depression: a potential new tool for diagnosis.Journal of affective disorders · 2014Article
- Prospective neurochemical characterization of child offspring of parents with bipolar disorder.Psychiatry research · 2013Article
- The neural effects of psychotropic medications in children and adolescents.Child and adolescent psychiatric clinics of North America · 2012Review
- Frontal lobe bioenergetic metabolism in depressed adolescents with bipolar disorder: a phosphorus-31 magnetic resonance spectroscopy study.Bipolar disorders · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveIdentifying neurochemical alterations in adolescent bipolar depression may enhance our understanding of the neurophysiology of bipolar disorder across the age spectrum. The objective of this study was to compare in vivo neurometabolite concentrations in bipolar adolescents with a depressed episode and healthy adolescents using proton magnetic resonance spectroscopy ((1)H MRS).
methodBipolar adolescents with a depressed episode (n = 28) and healthy adolescents (n = 10) underwent a (1)H MRS scan. Anterior cingulate (ACC) and left and right ventral lateral prefrontal (LVLPFC, RVLPFC) metabolite concentrations were calculated and compared between groups using analysis of covariance (ANCOVA).
resultsANCOVA showed significant group differences in ACC N-acetyl-aspartate (NAA) (F(1,33) = 17.8, p = 0.0002), LVLPFC choline (Cho) (F(1,32) = 13.1, p = 0.001), creatine/phosphocreatine (Cr) (F(1,32) = 18.5, p = 0.0002), and NAA (F(1,32) = 13.6, p = 0.0008), and RVLPFC Cr (F(1,32) = 9.6, p = 0.004), mI (F(1,32) = 11.1, p = 0.002), and NAA (F(1,32) = 11.4, p = 0.002) concentrations. In general, the bipolar depressed group had higher neurometabolite concentrations than the healthy group.
conclusionsThere may be localized alterations in brain neurometabolites in adolescents with bipolar depression. Limitations include lack of bipolar adolescents in other mood states and potential confounding effects of prior psychotropic medication use. Confirmatory (1)H MRS studies in larger samples of youths with bipolar depression are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.