ArticleInflammatory bowel diseases2009
Age of diagnosis influences serologic responses in children with Crohn's disease: a possible clue to etiology?
Article in Inflammatory bowel diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 84 citations in OpenAlex.
- Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study.Lancet (London, England) · 2017Trial
- Trial
- Comprehensive Association Analyses of Extraintestinal Manifestations in Inflammatory Bowel Disease.Gastroenterology · 2024Article
- Prognostic Factors of Biologic Therapy in Pediatric IBD.Children (Basel, Switzerland) · 2022Article
- Insurance Type Influences Access to Biologics and Healthcare Utilization in Pediatric Crohn's Disease.Crohn's & colitis 360 · 2021Article
- [Pediatric-onset Inflammatory Bowel Disease: What Are Different from Adult in the Treatment?]The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2021Review
- Utility of the combined use of 3 serologic markers in the diagnosis and monitoring of chronic enteropathies in dogs.Journal of veterinary internal medicine · 2021Article
- Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies.Inflammatory bowel diseases · 2020Review
- Serologic Reactivity Reflects Clinical Expression of Ulcerative Colitis in Children.Inflammatory bowel diseases · 2018Article
- Familial Association of Granulocyte-Macrophage Colony-Stimulating Factor Autoantibodies in Inflammatory Bowel Disease.Journal of pediatric gastroenterology and nutrition · 2018Article
- Eosinophilic colitis in children.Postepy dermatologii i alergologii · 2017Article
- The Role of Carrageenan and Carboxymethylcellulose in the Development of Intestinal Inflammation.Frontiers in pediatrics · 2017Review
- Very early-onset inflammatory bowel disease: gaining insight through focused discovery.Inflammatory bowel diseases · 2015Review
- Differential response to microbial antigens by age of diagnosis in patients with Crohn's disease.Clinical and experimental gastroenterology · 2015Article
- Effects of age at disease onset and at treatment on serology in inflammatory bowel diseases.Digestive diseases and sciences · 2015Article
- Very early-onset inflammatory bowel disease (IBD) in infancy is a different disease entity from adult-onset IBD; one form of interleukin-10 receptor mutations.Journal of human genetics · 2014Article
- New serological markers in pediatric patients with inflammatory bowel disease.World journal of gastroenterology · 2014Review
- NASPGHAN single-topic symposium: discovering the future of pediatric IBD care.Journal of pediatric gastroenterology and nutrition · 2014Article
- Serum anti-glycan antibodies in paediatric-onset Crohn's disease: association with disease phenotype and diagnostic accuracy.Przeglad gastroenterologiczny · 2014Article
- Update in pediatric inflammatory bowel disease.Rheumatic diseases clinics of North America · 2013Review
Corrections and comments
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Authors and funding
24 authors at 11 institutions in 2 countries.
Funding
Abstract
backgroundCrohn's disease (CD) is often associated with antibodies to microbial antigens. Differences in immune response may offer clues to the pathogenesis of the disease. The aim was to examine the influence of age at diagnosis on the serologic response in children with CD.
methodsData were drawn from 3 North American multicenter pediatric inflammatory bowel disease (IBD) research consortia. At or shortly after diagnosis, pANCA, ASCA IgA, ASCA IgG, anti-ompC, and anti-CBir1 were assayed. The results were compared as a function of age at CD diagnosis (0-7 years versus 8-15 years).
resultsIn all, 705 children (79 <8 years of age at diagnosis, 626 >or=8 years) were studied. Small bowel CD was less frequent in the younger group (48.7% versus 72.6%; P < 0.0001), while colonic involvement was comparable (91.0% versus 86.5%). ASCA IgA and IgG were seen in <20% of those 0-7 years old compared to nearly 40% of those 8-15 years old (P < 0.001), while anti-CBir1 was more frequent in the younger children (66% versus 54%, P < 0.05). Anti-CBir1 detected a significant number of children in both age groups who otherwise were serologically negative. Both age at diagnosis and site of CD involvement were independently associated with expression of ASCA and anti-CBir1.
conclusionsCompared to children 8-15 years of age at diagnosis, those 0-7 years are more likely to express anti-CBir1 but only half as likely to express ASCA. These age-associated differences in antimicrobial seropositivity suggest that there may be different, and as yet unrecognized, genetic, immunologic, and/or microbial factors leading to CD in the youngest children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.