ArticleThe Journal of comparative neurology2009
Expression of the regeneration-associated protein SPRR1A in primary sensory neurons and spinal cord of the adult mouse following peripheral and central injury.
Article in The Journal of comparative neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 75 citations in OpenAlex.
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- Scorpion (Hottentotta tamulus) venom pre-exposure delays functional recovery in mice following peripheral nerve injury.PloS one · 2025Article
- Single-cell transcriptomic profiling of dorsal root ganglion: an overview.Frontiers in neuroanatomy · 2023Review
- Precision, integrative medicine for pain management in sickle cell disease.Frontiers in pain research (Lausanne, Switzerland) · 2023Review
- Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons.Nature communications · 2022Article
- Histone modification of pain-related gene expression in spinal cord neurons under a persistent postsurgical pain-like state by electrocautery.Molecular brain · 2021Article
- The integrated stress response contributes to tRNA synthetase-associated peripheral neuropathy.Science (New York, N.Y.) · 2021Article
- Optic nerve regeneration screen identifies multiple genes restricting adult neural repair.Cell reports · 2021Article
- Genetic priming of sensory neurons in mice that overexpress PAR2 enhances allergen responsiveness.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Current Status of Therapeutic Approaches against Peripheral Nerve Injuries: A Detailed Story from Injury to Recovery.International journal of biological sciences · 2020Review
- Biomechanical Forces Regulate Gene Transcription During Stretch-Mediated Growth of Mammalian Neurons.Frontiers in neuroscience · 2020Article
- Detection of local and remote cellular damage caused by spinal cord and peripheral nerve injury using a heat shock signaling reporter system.IBRO reports · 2018Article
- Salivary exRNA biomarkers to detect gingivitis and monitor disease regression.Journal of clinical periodontology · 2018Article
- Regenerative effects of human embryonic stem cell-derived neural crest cells for treatment of peripheral nerve injury.Journal of tissue engineering and regenerative medicine · 2018Article
- Defining a mechanistic link between pigment epithelium-derived factor, docosahexaenoic acid, and corneal nerve regeneration.The Journal of biological chemistry · 2017Article
- Postinjury Induction of Activated ErbB2 Selectively Hyperactivates Denervated Schwann Cells and Promotes Robust Dorsal Root Axon Regeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Neuronal aromatase expression in pain processing regions of the medullary and spinal cord dorsal horn.The Journal of comparative neurology · 2017Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Small proline-rich repeat protein 1A (SPRR1A) is expressed in dorsal root ganglion (DRG) neurons following peripheral nerve injury but it is not known whether SPRR1A is differentially expressed following injury to peripheral versus central DRG projections and a detailed characterization of expression in sensory neuron subpopulations and spinal cord has not been performed. Here we use immunocytochemical techniques to characterize SPRR1A expression following sciatic nerve, dorsal root, and dorsal column injury in adult mice. SPRR1A was not detected in naïve spinal cord, DRG, or peripheral nerves and there was minimal expression following injury to the centrally projecting branches of DRG neurons. However, following peripheral (sciatic) nerve injury, intense SPRR1A immunoreactivity was observed in the dorsal horn and motoneurons of the spinal cord, in L4/5 DRG neurons, and in the injured nerve. A time-course study comparing expression following sciatic nerve crush and transection revealed maximum SPRR1A levels at day 7 in both models. However, while SPRR1A was downregulated to baseline by 30 days postlesion following crush injury, it remained elevated 30 days after transection. Cell-size and double-labeling studies revealed that SPRR1A was expressed by DRG cells of all sizes and colocalized with classical markers of DRG subpopulations and their primary afferent terminals. High coexpression of SPRR1A with activating transcription factor-3 and growth-associated protein-43 was observed, indicating that it is expressed by injured and regenerating neurons. This study supports the hypothesis that SPRR1A is a regeneration-associated gene and that SPRR1A provides a valuable marker to assess the regenerative potential of injured neurons.
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