ArticleMolecular biology reports2009
Estrogen regulates DNA methyltransferase 3B expression in Ishikawa endometrial adenocarcinoma cells.
Article in Molecular biology reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- The Detrimental Impact of Bisphenol S (BPS) on Trophoblastic Cells and the Ishikawa Cell Lines: An In Vitro Model of Cytotoxic Effect and Molecular Interactions.Biomedicines · 2025Article
- Mechanisms underlying sex differences in autoimmunity.The Journal of clinical investigation · 2024Review
- An epigenome-wide analysis of sex hormone levels and DNA methylation in male blood samples.Epigenetics · 2023Article
- Novel role for conceptus signals in mRNA expression regulation by DNA methylation in porcine endometrium during early pregnancy†.Biology of reproduction · 2023Article
- The steroid hormone estriol (EBMC biology · 2022Article
- Pre-pubertal oocytes harbor altered histone modifications and chromatin configuration.Frontiers in cell and developmental biology · 2022Article
- Estradiol-17β Regulates Expression of Luteal DNA Methyltransferases and Genes Involved in the Porcine Corpus Luteum Function In Vivo.International journal of molecular sciences · 2021Article
- Targeting Epigenetic Regulators for Endometrial Cancer Therapy: Its Molecular Biology and Potential Clinical Applications.International journal of molecular sciences · 2021Review
- Chronic Exposure of Mice to Bisphenol-A Alters Uterine Fibroblast Growth Factor Signaling and Leads to Aberrant Epithelial Proliferation.Endocrinology · 2019Article
- 17β-Estradiol and 17α-Ethinyl Estradiol Exhibit Immunologic and Epigenetic Regulatory Effects in NZB/WF1 Female Mice.Endocrinology · 2019Article
- Endocrine-disrupting chemicals, epigenetics, and skeletal system dysfunction: exploration of links using bisphenol A as a model system.Environmental epigenetics · 2018Article
- Our Environment Shapes Us: The Importance of Environment and Sex Differences in Regulation of Autoantibody Production.Frontiers in immunology · 2018Review
- ERα propelled aberrant global DNA hypermethylation by activating the DNMT1 gene to enhance anticancer drug resistance in human breast cancer cells.Oncotarget · 2016Article
- Aberrant methylation of imprinted genes is associated with negative hormone receptor status in invasive breast cancer.International journal of cancer · 2015Article
- Genome-wide DNA methylation analysis reveals estrogen-mediated epigenetic repression of metallothionein-1 gene cluster in breast cancer.Clinical epigenetics · 2015Article
- Dysregulated transcriptional and post-translational control of DNA methyltransferases in cancer.Cell & bioscience · 2014Review
- The many faces of estrogen signaling.Biochemia medica · 2014Review
- DNA methyltransferases and TETs in the regulation of differentiation and invasiveness of extra-villous trophoblasts.Frontiers in genetics · 2013Review
- Epigenetic regulation of estrogen signaling in breast cancer.Epigenetics · 2013Review
- Hormonally mediated epigenetic changes to steroid receptors in the developing brain: implications for sexual differentiation.Hormones and behavior · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well-known that exposure to unopposed estrogen is considered as an important risk factor for endometrial cancer. Recent studies have shown that over-expression of DNA methyltransferases (DNMTs) are involved in the development of endometrial cancer. Therefore, the present study was undertaken to elucidate the impact of estrogen on the expression of DNMTs in endometrial cancer. Ishikawa cell line was used. Flow cytometry analysis demonstrated that 17 beta-estradiol (E(2)) enhanced the cell proliferation with a peak at 10(-8) M. Over-expression of DNMT3B treated with E(2) was confirmed by real-time PCR and western blotting analysis. Furthermore, the up-regulation of DNMT3B expression induced by E(2) was suppressed by the addition of ICI182780. However, we did not observe changes in the expression of DNMT1. Our study suggests that estrogen up-regulating the expression of DNMT3B in an ER-dependent pathway may be a possible mechanism for estrogen facilitates the malignant transformation of endometrial cancer cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.