ArticleFunctional & integrative genomics2009
Insulin regulates milk protein synthesis at multiple levels in the bovine mammary gland.
Article in Functional & integrative genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 126 citations in OpenAlex.
- Feasibility and Acceptability of Metformin to Augment Low Milk Supply: A Pilot Randomized Controlled Trial.Journal of human lactation : official journal of International Lactation Consultant Association · 2019Trial
- Short-term modulation of human milk oligosaccharides in plasma and milk by glucose and insulin: insights into postpartum metabolic regulation.Diabetologia · 2026Article
- Response of mid-lactation primiparous Holstein cows to the supplementation of rumen-protected methionine during the summer.PloS one · 2026Article
- Lifetime performance traits of Holstein cows: implications of first-lactation milk yield and culling causes.Tropical animal health and production · 2025Article
- Breastfeeding patterns among parturients with diabetes: a secondary analysis of the MOMPOD randomized clinical trial.Pregnancy (Hoboken, N.J.) · 2025Article
- Review
- Whole Genome Scan Uncovers Candidate Genes Related to Milk Production Traits in Barka Cattle.International journal of molecular sciences · 2024Article
- The Role of Progesterone in Elf5 Activation and Milk Component Synthesis for Cell-Cultured Milk Production in MAC-T Cells.Animals : an open access journal from MDPI · 2024Article
- Causes of Low Milk Supply: The Roles of Estrogens, Progesterone, and Related External Factors.Advances in nutrition (Bethesda, Md.) · 2024Review
- Alterations of milk oligosaccharides in mothers with gestational diabetes mellitus impede colonization of beneficial bacteria and development of RORγtGut microbes · 2023Article
- Culture Models to Investigate Mechanisms of Milk Production and Blood-Milk Barrier in Mammary Epithelial Cells: a Review and a Protocol.Journal of mammary gland biology and neoplasia · 2023Review
- The functional and regulatory entities underlying free and peptide-bound amino acid transporters in the bovine mammary gland.JDS communications · 2023Review
- Review
- Plasma Proteomic Profiling Reveals the Regulatory Factors of Milk Protein Synthesis in Holstein Cows.Biology · 2022Article
- Developing dietary interventions as therapy for cancer.Nature reviews. Cancer · 2022Review
- Measures of Maternal Metabolic Health as Predictors of Severely Low Milk Production.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2022Article
- Beta-Sitosterol Promotes Milk Protein and Fat Syntheses-Related Genes in Bovine Mammary Epithelial Cells.Animals : an open access journal from MDPI · 2021Article
- Transcriptome Adaptation of the Ovine Mammary Gland to Dietary Supplementation of Extruded Linseed.Animals : an open access journal from MDPI · 2021Article
- Genome-Wide SNP Analysis for Milk Performance Traits in Indigenous Sheep: A Case Study in the Egyptian Barki Sheep.Animals : an open access journal from MDPI · 2021Article
- A Comparative Review of the Extrinsic and Intrinsic Factors Regulating Lactose Synthesis.Journal of mammary gland biology and neoplasia · 2021Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of insulin in milk protein synthesis is unresolved in the bovine mammary gland. This study examined the potential role of insulin in the presence of two lactogenic hormones, hydrocortisone and prolactin, in milk protein synthesis. Insulin was shown to stimulate milk protein gene expression, casein synthesis and (14)C-lysine uptake in mammary explants from late pregnant cows. A global assessment of changes in gene expression in mammary explants in response to insulin was undertaken using Affymetrix microarray. The resulting data provided insight into the molecular mechanisms stimulated by insulin and showed that the hormone stimulated the expression of 28 genes directly involved in protein synthesis. These genes included the milk protein transcription factor, ELF5, translation factors, the folate metabolism genes, FOLR1 and MTHFR, as well as several genes encoding enzymes involved in catabolism of essential amino acids and biosynthesis of non-essential amino acids. These data show that insulin is not only essential for milk protein gene expression, but stimulates milk protein synthesis at multiple levels within bovine mammary epithelial cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.