ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2009
Hydrogen peroxide at a concentration used during neurosurgery disrupts ciliary function and causes extensive damage to the ciliated ependyma of the brain.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- High-Speed Video Microscopy of Ependymal Cilia in Brain Organotypic and Cell Culture Models.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Posttraumatic hydrocephalus: Recent advances and new therapeutic strategies.Health science reports · 2023Article
- Prediction of adult post-hemorrhagic hydrocephalus: a risk score based on clinical data.Scientific reports · 2022Article
- Loss of cAMP-dependent stimulation of isolated cilia motility by alcohol exposure is oxidant-dependent.Alcohol (Fayetteville, N.Y.) · 2019Article
- Morphological Changes within the Rat Lateral Ventricle after the Administration of Proteasome Inhibitors.PloS one · 2015Article
- Peroxiredoxin VI oxidation in cerebrospinal fluid correlates with traumatic brain injury outcome.Free radical biology & medicine · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
objectivesHydrogen peroxide [H(2)O(2): 3% w/v (1.1 M)] has been used as a haemostatic agent during neurosurgery applied to both the external and ventricular surface of the brain. We hypothesised that H(2)O(2) would be toxic to the ciliated ependyma, a single layer of cells that separates cerebrospinal fluid from the neuronal tissue of the brain. MATERIALS AND
methodsThe effect of H(2)O(2) was assessed by determining ependymal ciliary beat frequency (CBF) using high-speed video analysis and ultrastructure by electron microscopy.
resultsBrief exposure to H(2)O(2) caused cessation of ciliary beat frequency and extensive damage of the ependyma.
conclusionsDamage to the ciliated ependyma is of concern, as regeneration following damage is very poor and if breached underlying neuronal tissue and a population of neuronal progenitor cells that lie immediately beneath may also be exposed to H(2)O(2).
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