ArticlePloS one2008
Global expression profiling in atopic eczema reveals reciprocal expression of inflammatory and lipid genes.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Meta-analysis derived atopic dermatitis (MADAD) transcriptome defines a robust AD signature highlighting the involvement of atherosclerosis and lipid metabolism pathways.BMC medical genomics · 2015Pooled it
- Trial
- Investigating Transcriptional Age Acceleration in Inflammatory Skin Diseases.JID innovations : skin science from molecules to population health · 2025Article
- Transglutaminase 1: Emerging Functions beyond Skin.International journal of molecular sciences · 2024Review
- Systemic inflammatory proteins in offspring following maternal probiotic supplementation for atopic dermatitis prevention.Clinical and molecular allergy : CMA · 2023Article
- Immunomodulatory Effect of Epidermal Growth Factor Secreted by Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells on Atopic Dermatitis.International journal of stem cells · 2022Article
- Integrative analysis to explore the biological association between environmental skin diseases and ambient particulate matter.Scientific reports · 2022Article
- Microbial and transcriptional differences elucidate atopic dermatitis heterogeneity across skin sites.Allergy · 2021Article
- The desmosome as a model for lipid raft driven membrane domain organization.Biochimica et biophysica acta. Biomembranes · 2020Review
- Igalan from Inula helenium (L.) suppresses the atopic dermatitis-like response in stimulated HaCaT keratinocytes via JAK/STAT3 signaling.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020Article
- Review-Current Concepts in Inflammatory Skin Diseases Evolved by Transcriptome Analysis: In-Depth Analysis of Atopic Dermatitis and Psoriasis.International journal of molecular sciences · 2020Review
- Host Responses in anFrontiers in cellular and infection microbiology · 2020Article
- Association of Key Genes and Pathways with Atopic Dermatitis by Bioinformatics Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- The Skin Commensal Yeast Malassezia globosa Thwarts Bacterial Biofilms to Benefit the Host.The Journal of investigative dermatology · 2018Article
- Leveraging Multilayered "Omics" Data for Atopic Dermatitis: A Road Map to Precision Medicine.Frontiers in immunology · 2018Review
- CD1a presentation of endogenous antigens by group 2 innate lymphoid cells.Science immunology · 2017Article
- An epigenome-wide association study of total serum IgE in Hispanic children.The Journal of allergy and clinical immunology · 2017Article
- SERPINB3 and B4: From biochemistry to biology.Seminars in cell & developmental biology · 2017Review
- Atopic Dermatitis Studies throughFrontiers in medicine · 2017Review
- Global gene regulation during activation of immunoglobulin class switching in human B cells.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtopic eczema (AE) is a common chronic inflammatory skin disorder. In order to dissect the genetic background several linkage and genetic association studies have been performed. Yet very little is known about specific genes involved in this complex skin disease, and the underlying molecular mechanisms are not fully understood. METHODOLOGY/
findingsWe used human DNA microarrays to identify a molecular picture of the programmed responses of the human genome to AE. The transcriptional program was analyzed in skin biopsy samples from lesional and patch-tested skin from AE patients sensitized to Malassezia sympodialis (M. sympodialis), and corresponding biopsies from healthy individuals. The most notable feature of the global gene-expression pattern observed in AE skin was a reciprocal expression of induced inflammatory genes and repressed lipid metabolism genes. The overall transcriptional response in M. sympodialis patch-tested AE skin was similar to the gene-expression signature identified in lesional AE skin. In the constellation of genes differentially expressed in AE skin compared to healthy control skin, we have identified several potential susceptibility genes that may play a critical role in the pathological condition of AE. Many of these genes, including genes with a role in immune responses, lipid homeostasis, and epidermal differentiation, are localized on chromosomal regions previously linked to AE. CONCLUSIONS/SIGNIFICANCE: Through genome-wide expression profiling, we were able to discover a distinct reciprocal expression pattern of induced inflammatory genes and repressed lipid metabolism genes in skin from AE patients. We found a significant enrichment of differentially expressed genes in AE with cytobands associated to the disease, and furthermore new chromosomal regions were found that could potentially guide future region-specific linkage mapping in AE. The full data set is available at http://microarray-pubs.stanford.edu/eczema.
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