ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2009
Mucosal tolerance to E-selectin promotes the survival of newly generated neuroblasts via regulatory T-cell induction after stroke in spontaneously hypertensive rats.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 59 citations in OpenAlex.
- Regulatory T cells in stroke inflammation: Therapeutic perspectives.Neural regeneration research · 2026Article
- Water-Soluble Lynx1 Upregulates Dendritic Spine Density and Stimulates Astrocytic Network and Signaling.Molecular neurobiology · 2025Article
- Role of Regulatory T Cells in Intracerebral Hemorrhage.Molecular neurobiology · 2025Review
- New insights into the biological roles of immune cells in neural stem cells in post-traumatic injury of the central nervous system.Neural regeneration research · 2023Review
- Preferential delivery of lipid-ligand conjugated DNA/RNA heteroduplex oligonucleotide to ischemic brain in hyperacute stage.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Article
- Regulatory T cells in ischemic stroke.Acta pharmacologica Sinica · 2022Review
- Cryptotanshinone possesses therapeutic effects on ischaemic stroke through regulating STAT5 in a rat model.Pharmaceutical biology · 2021Article
- The effect of fingolimod on regulatory T cells in a mouse model of brain ischaemia.Journal of neuroinflammation · 2021Article
- The spleen may be an important target of stem cell therapy for stroke.Journal of neuroinflammation · 2019Review
- Autoimmunity After Ischemic Stroke and Brain Injury.Frontiers in immunology · 2019Review
- The evolving role of neuro-immune interaction in brain repair after cerebral ischemic stroke.CNS neuroscience & therapeutics · 2018Review
- Neuroprotective Effects of MAGL (Monoacylglycerol Lipase) Inhibitors in Experimental Ischemic Stroke.Stroke · 2018Article
- Regulatory T cells ameliorate tissue plasminogen activator-induced brain haemorrhage after stroke.Brain : a journal of neurology · 2017Article
- Regulatory T cells exhibit neuroprotective effect in a mouse model of traumatic brain injury.Molecular medicine reports · 2016Article
- Regulatory T Cell Therapy for Ischemic Stroke: how far from Clinical Translation?Translational stroke research · 2016Article
- Regulatory T Cells in Post-stroke Immune Homeostasis.Translational stroke research · 2016Review
- Inflammatory Disequilibrium in Stroke.Circulation research · 2016Review
- Review
- Regulatory T cells modulate inflammation and reduce infarct volume in experimental brain ischaemia.Journal of cellular and molecular medicine · 2014Article
- Molecular dialogs between the ischemic brain and the peripheral immune system: dualistic roles in injury and repair.Progress in neurobiology · 2014Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Neuroblasts in the subventricular zone (SVZ) proliferate markedly after brain ischemia, and migrate to the site of injury along with blood vessels. However, a large fraction of stroke-generated neuroblasts die shortly after being born, in part, because of local inflammation. In spontaneously hypertensive rats (SHRs) subjected to permanent middle cerebral artery occlusion, we primed E-selectin-specific regulatory T cells (Tregs) by repetitive intranasal administration of recombinant E-selectin to target local secretion of immunomodulating, antiinflammatory cytokines to activating blood vessel segments. E-selectin-tolerized SHRs had decreased infarction volumes, and increased numbers of Tregs in the cervical lymph nodes and ischemic brain. The brain Tregs were distributed primarily in periinfarct regions. E-selectin tolerization did not alter cellular proliferation in the ipsilateral SVZ after stroke, but the expression of tumor necrosis factor on vascular niche blood vessels was suppressed and both doublecortin protein levels and the number of newly generated neuroblasts or neurons were increased in the brain. This enhanced survival of neural progenitor cells and neurons was paralleled by improved functional performance. These studies suggest that E-selectin-specific Tregs can modulate the efficacy of neurogenesis after ischemia and promote repair after brain injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.