ReviewCurrent opinion in allergy and clinical immunology2009
Interactions between helminth parasites and allergy.
Review in Current opinion in allergy and clinical immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
92 citing papers in PubMed, 2 syntheses or guidelines pooled it, 204 citations in OpenAlex.
- The Association between Migration and Prevalence of Allergic Diseases: A Systematic Review and Meta-Analysis.International archives of allergy and immunology · 2024Pooled it
- Anthelmintic drugs for treating ascariasis.The Cochrane database of systematic reviews · 2020Pooled it
- Does treatment of intestinal helminth infections influence malaria? Background and methodology of a longitudinal study of clinical, parasitological and immunological parameters in Nangapanda, Flores, Indonesia (ImmunoSPIN Study).BMC infectious diseases · 2010Trial
- Non-syndromic hyper-IgE in children: A practical approach.The World Allergy Organization journal · 2026Review
- CouldFrontiers in allergy · 2026Article
- A survey of pathogenic involvement in non-communicable human diseases.Communications medicine · 2025Article
- Soil-Transmitted Helminths and the Intricacies of Immunoregulation: Evidence From Amazonian Ecuador for the Importance of Considering Species-Specific Effects Within the Old Friends Hypothesis.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- The role of immunoglobulin E in non-atopic disorders.Frontiers in immunology · 2025Review
- Environmental exposures associated with atopy in a rural community in Gwanda district, Zimbabwe: a cross-sectional study.Frontiers in public health · 2024Article
- Food Allergies and Parasites in Children.Foods (Basel, Switzerland) · 2023Review
- Feline heartworm disease and environmental allergens hypersensitivity: is there a link?Parasites & vectors · 2023Article
- Toxocariasis: potential association with bronchial asthma, and pneumonia among pediatric children.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2023Article
- Machine learning-based risk factor analysis and prevalence prediction of intestinal parasitic infections using epidemiological survey data.PLoS neglected tropical diseases · 2022Article
- Concurrent allergy and helminthiasis in underprivileged urban South African adults previously residing in rural areas.Parasite immunology · 2022Article
- Allergic asthma manifestations in human and seropositivity toFrontiers in medicine · 2022Article
- Field evaluation of the gut microbiome composition of pre-school and school-aged children in Tha Song Yang, Thailand, following oral MDA for STH infections.PLoS neglected tropical diseases · 2021Article
- Allergen-Specific Treg Cells Upregulated by Lung-StageFrontiers in cell and developmental biology · 2021Article
- Impact of parasitic infection withRespiratory medicine case reports · 2021Article
- Diversity of Microbial Signatures in Asthmatic Airways.International journal of general medicine · 2021Review
- Understanding Asthma and Allergies by the Lens of Biodiversity and Epigenetic Changes.Frontiers in immunology · 2021Review
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 2 countries.
Funding
Abstract
purpose of reviewTo review the findings of recent human studies of the association between helminth parasite infections and allergy and discuss their potential relevance to public health. RECENT
findingsDifferent helminth parasites may have different effects on allergy that may depend on the timing or intensity of the exposure or host genetic factors. Infections with Trichuris trichiura in early life are associated with a reduced prevalence of allergen skin test reactivity later in life and infants of helminth-infected mothers have been reported to have a reduced prevalence of eczema. Hookworm infection has been associated with a reduced prevalence of asthma in Ethiopia. Several studies have reported that anti-Ascaris IgE is an important risk factor for asthma, but this could be explained by an enhanced ability of atopics to produce IgE. Toxocara infections may be associated with an increased risk of wheeze in some populations that may be caused by the host response to the parasite or by parasite-enhanced Th2 responses to aeroallergens. SUMMARY: Although helminth infections can modulate the host inflammatory response directed against the parasite, a causal association between helminths and atopic diseases remains uncertain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.