Evidence map›Paper›PMID 19106630›Full record

ReviewRNA biology

Transcriptional control of microRNA expression in C. elegans: promoting better understanding.

Michael J Turner, Frank J Slack

Abstract readReview
In one paragraph

Review in RNA biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Hormone-dependent activation and repression of microRNAs by the ecdysone receptor in the dengue vector mosquitoProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  3. Review
  4. Article
  5. STAT3 Regulates miR-384 Transcription During Th17 Polarization.Frontiers in cell and developmental biology · 2019
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. miRNAs give worms the time of their lives: small RNAs and temporal control in Caenorhabditis elegans.Developmental dynamics : an official publication of the American Association of Anatomists · 2010
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Michael J TurnerDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA.
Frank J Slack

Funding

MicroRNAs in agingR01AG033921 · NIA · YALE UNIVERSITY · PI SLACK, FRANK J. · 2009 to 2018
$3.3M
Heterochronic control of development and lifespanR01GM064701 · NIGMS · YALE UNIVERSITY · PI SLACK, FRANK J. · 2002 to 2010
$2.0M
NIA NIH HHS R01 AG033921NIGMS NIH HHS GM64701NIGMS NIH HHS R01 GM064701
6 · The paper itself

Abstract

Transcriptional regulation of microRNA (miRNA) expression is one of the least understood aspects of miRNA biogenesis. In C. elegans the list of miRNAs whose transcriptional control has been described in some detail is currently limited to four: let-7, lin-4, lsy-6, and mir-61. Each of these genes has been shown experimentally to be transcriptionaly regulated by cis- and/or trans-acting factors that either promote or inhibit expression. Additionally, computational methods based on conservation among miRNA genes have yielded predicted regulatory sequences in C. elegans that may function to regulate miRNA expression on a genome-wide scale.

Indexed as

Transcription, GeneticAmino Acid MotifsAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsEnhancer Elements, GeneticGene Expression RegulationGenes, HelminthGenome, HelminthMicroRNAsModels, GeneticPromoter Regions, GeneticSoftwareCaenorhabditis elegans ProteinsMicroRNAs

Identifiers

PMID19106630
PMCPMC4311750

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.