Evidence map›Paper›PMID 19106272›Full record

ArticleThe Journal of clinical endocrinology and metabolism2009

Association between vitamin D deficiency and primary cesarean section.

Anne Merewood, Supriya D Mehta, Tai C Chen, Howard Bauchner, Michael F Holick

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

132 citing papers in PubMed, 11 syntheses or guidelines pooled it.

  1. Vitamin D supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2024
    Pooled it
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  4. Vitamin D supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2019
    Pooled it
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  6. Vitamin D supplementation during pregnancy: Updated meta-analysis on maternal outcomes.The Journal of steroid biochemistry and molecular biology · 2016
    Pooled it
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  10. Vitamin D in pregnancy: current concepts.Current opinion in obstetrics & gynecology · 2012
    Pooled it
  11. Vitamin D supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2012
    Pooled it
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  19. Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011
    Trial
  20. Review

72 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anne MerewoodDepartment of Pediatrics, Division of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, and Division of General Pediatrics, Boston Medical Center, Boston, Massachusetts 02118, USA.
Supriya D Mehta
Tai C Chen
Howard Bauchner
Michael F Holick

Funding

PHS HHS R40MC03620-02-00
6 · The paper itself

Abstract

backgroundAt the turn of the 20th century, women commonly died in childbirth due to rachitic pelvis. Although rickets virtually disappeared with the discovery of the hormone vitamin D, recent reports suggest vitamin D deficiency is widespread in industrialized nations. Poor muscular performance is an established symptom of vitamin D deficiency. The current U.S. cesarean birth rate is at an all-time high of 30.2%. We analyzed the relationship between maternal serum 25-hydroxyvitamin D [25(OH)D] status, and prevalence of primary cesarean section.

methodsBetween 2005 and 2007, we measured maternal and infant serum 25(OH)D at birth and abstracted demographic and medical data from the maternal medical record at an urban teaching hospital (Boston, MA) with 2500 births per year. We enrolled 253 women, of whom 43 (17%) had a primary cesarean.

resultsThere was an inverse association with having a cesarean section and serum 25(OH)D levels. We found that 28% of women with serum 25(OH)D less than 37.5 nmol/liter had a cesarean section, compared with only 14% of women with 25(OH)D 37.5nmol/liter or greater (P = 0.012). In multivariable logistic regression analysis controlling for race, age, education level, insurance status, and alcohol use, women with 25(OH)D less than 37.5 nmol/liter were almost 4 times as likely to have a cesarean than women with 25(OH)D 37.5 nmol/liter or greater (adjusted odds ratio 3.84; 95% confidence interval 1.71 to 8.62).

conclusionVitamin D deficiency was associated with increased odds of primary cesarean section.

Indexed as

AdultCalciumCesarean SectionFemaleHumansInfant, NewbornLogistic ModelsMalePregnancyVitamin DVitamin D Deficiency25-hydroxyvitamin DCalciumVitamin D

Identifiers

PMID19106272
PMCPMC2681281

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.