ArticleThe Journal of biological chemistry2009
PEP-19, an intrinsically disordered regulator of calmodulin signaling.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 51 citations in OpenAlex.
- Neurogranin modulates the rate of association between calmodulin and target peptides.Biophysical journal · 2024Article
- Immunohistochemical field parcellation of the human hippocampus along its antero-posterior axis.Brain structure & function · 2024Article
- Screening and validation of plasma cell-derived, purinergic, and calcium signalling-related genetic signature to predict prognosis and PD-L1/PD-1 blockade responses in lung adenocarcinoma.Journal of cancer research and clinical oncology · 2023Article
- Identification of potential lncRNA-miRNA-mRNA regulatory network contributing to aldosterone-producing adenoma.Journal of cellular and molecular medicine · 2022Article
- Perineuronal net degradation rescues CA2 plasticity in a mouse model of Rett syndrome.The Journal of clinical investigation · 2021Article
- Juvenile Huntington's Disease and Other PolyQ Diseases, Update on Neurodevelopmental Character and Comparative Bioinformatic Review of Transcriptomic and Proteomic Data.Frontiers in cell and developmental biology · 2021Review
- Identification and validation of a novel anti-virulent that binds to pyoverdine and inhibits its function.Virulence · 2020Article
- Calcium-Binding Proteins with Disordered Structure and Their Role in Secretion, Storage, and Cellular Signaling.Biomolecules · 2018Review
- Arabidopsis PCaP2 Functions as a Linker Between ABA and SA Signals in Plant Water Deficit Tolerance.Frontiers in plant science · 2018Article
- PEP-19 modulates calcium binding to calmodulin by electrostatic steering.Nature communications · 2016Article
- PCP4/PEP19 promotes migration, invasion and adhesion in human breast cancer MCF-7 and T47D cells.Oncotarget · 2016Article
- A novel-type phosphatidylinositol phosphate-interactive, Ca-binding protein PCaP1 in Arabidopsis thaliana: stable association with plasma membrane and partial involvement in stomata closure.Journal of plant research · 2016Article
- Relative Cosolute Size Influences the Kinetics of Protein-Protein Interactions.Biophysical journal · 2015Article
- The exchanged EF-hands in calmodulin and troponin C chimeras impair the Ca²⁺-induced hydrophobicity and alter the interaction with Orai1: a spectroscopic, thermodynamic and kinetic study.BMC biochemistry · 2015Article
- PCP4 regulates Purkinje cell excitability and cardiac rhythmicity.The Journal of clinical investigation · 2014Article
- Structural and thermodynamic characterization of the recognition of the S100-binding peptides TRTK12 and p53 by calmodulin.Protein science : a publication of the Protein Society · 2014Article
- Anti-apoptotic effects of PCP4/PEP19 in human breast cancer cell lines: a novel oncotarget.Oncotarget · 2014Article
- Neurogranin alters the structure and calcium binding properties of calmodulin.The Journal of biological chemistry · 2014Article
- Distinct physiological and developmental properties of hippocampal CA2 subfield revealed by using anti-Purkinje cell protein 4 (PCP4) immunostaining.The Journal of comparative neurology · 2014Article
- PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues.Journal of molecular endocrinology · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
PEP-19 is a small calmodulin (CaM)-binding protein that greatly increases the rates of association and dissociation of Ca(2+) from the C-domain of CaM, an effect that is mediated by an acidic/IQ sequence in PEP-19. We show here using NMR that PEP-19 is an intrinsically disordered protein, but with residual structure localized to its acidic/IQ motif. We also show that the k(on) and k(off) rates for binding PEP-19 to apo-CaM are at least 50-fold slower than for binding to Ca(2+)-CaM. These data indicate that intrinsic disorder confers plasticity that allows PEP-19 to bind to either apo- or Ca(2+)-CaM via different structural modes, and that complex formation may be facilitated by conformational selection of residual structure in the acidic/IQ sequence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.