Evidence map›Paper›PMID 19105846›Full record

ArticleJournal of translational medicine2008

A systematic approach to biomarker discovery; preamble to "the iSBTc-FDA taskforce on immunotherapy biomarkers".

Lisa H Butterfield, Mary L Disis, Bernard A Fox, Peter P Lee, Samir N Khleif, Magdalena Thurin, Giorgio Trinchieri, Ena Wang, Jon Wigginton, Damien Chaussabel and 27 more

2 registry-linked trialsOpen access · goldAbstract readEditorial
In one paragraph

Article in Journal of translational medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01858649 phase2completednot on this mapstarted 2013, after this paper: background citation

Randomized Phase 2 Study Comparing Pathological Responses on Colorectal Cancer Metastases After Preoperative Treatment Combining Bevacizumab With FOLFOX or FOLFIRI

TypeinterventionalSponsorCliniques universitaires Saint-Luc- Université Catholique de LouvainRan2013 to 2019Enrolled60ConditionsMetastatic Colorectal CancerArmsMetastases resection, Bevacizumab, 5 FU, Oxaliplatin, Irinotecan
NCT01858662 phase2terminatednot on this mapstarted 2014, after this paper: background citation

Randomised Phase 2 Study Comparing Pathological Responses Observed on Colorectal Cancer Metastases Resected After Preoperative Treatment Combining Cetuximab With FOLFOX or FOLFIRI in RAS and B-RAF WT Tumors

TypeinterventionalSponsorCliniques universitaires Saint-Luc- Université Catholique de LouvainRan2014 to 2015Enrolled4ConditionsMetastatic Colorectal CancerArmsMetastases Resection ( multiple steep surgery possible), 5-Fluorouracile, leucovorin L, Oxaliplatin, Irinotecan
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Preamble to the 2015 SITC immunotherapy biomarkers taskforce.Journal for immunotherapy of cancer · 2015
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Defining the critical hurdles in cancer immunotherapy.Journal of translational medicine · 2011
    Article
  11. Article
  12. Article
  13. Article
  14. Biomarkers in T cell therapy clinical trials.Journal of translational medicine · 2011
    Review
  15. Article
  16. Dendritic cell subsets as vectors and targets for improved cancer therapy.Current topics in microbiology and immunology · 2011
    Review
  17. Article
  18. Response definition criteria for ELISPOT assays revisited.Cancer immunology, immunotherapy : CII · 2010
    Article
  19. New technologies for autoimmune disease monitoring.Current opinion in endocrinology, diabetes, and obesity · 2010
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 20 institutions in 5 countries.

Lisa H ButterfieldDepartment of Medicine, Division of Hematology Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, 15213, USA. butterfieldl@upmc.edu
Mary L Disis
Bernard A Fox
Peter P Lee
Samir N Khleif
Magdalena Thurin
Giorgio Trinchieri
Ena Wang
Jon Wigginton
Damien Chaussabel
George Coukos
Madhav Dhodapkar
Leif Håkansson
Sylvia Janetzki
Thomas O Kleen
John M Kirkwood
Cristina Maccalli
Holden Maecker
Michele Maio
Anatoli Malyguine
Giuseppe Masucci
A Karolina Palucka
Douglas M Potter
Antoni Ribas
Licia Rivoltini
Dolores Schendel
Barbara Seliger
Senthamil Selvan
Craig L Slingluff
David F Stroncek
Howard Streicher
Xifeng Wu
Benjamin Zeskind
Yingdong Zhao
Mai-Britt Zocca
Heinz Zwierzina
Francesco M Marincola
Baylor University · USNational Institutes of Health Clinical Center · USUPMC Hillman Cancer Center · USBristol-Myers Squibb (United States) · USCenter for Cancer Research · USFondazione IRCCS Istituto Nazionale dei Tumori · ITHelmholtz Zentrum München · DEHoag Memorial Hospital Presbyterian · USImmuneering (United States)Innsbruck Medical University · ATKarolinska Institutet · SELund University · SEMartin Luther University Halle-Wittenberg · DENational Cancer Institute · USNational Institutes of Health · USOffice of Research Services · USOregon Health & Science University · USScience Applications International Corporation (United States) · USShaker Heights Public Library · USStanford University · US

Funding

Role of inflammation, innate resistance, and immunity in carcinogenesis.ZIABC010793 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TRINCHIERI, GIORGIO · 2009 to 2025
$16.8M
Role of inflammation, innate resistance, and immunity in carcinogenesis.Z01BC010793 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TRINCHIERI, GIORGIO · 2007 to 2008
$4.2M
Immunogenetic Study of Infectious Diseases and CancerZ01CL002118 · CLC · CLINICAL CENTER · PI MARINCOLA, FRANCESCO M · 2007 to 2008
$1.4M
Immunogenetics of Vaccine TherapyZIACL002115 · CLC · CLINICAL CENTER · PI MARINCOLA, FRANCESCO M · 2009 to 2010
$0k
Immunogenetic Study of Infectious Diseases and CancerZIACL002118 · CLC · CLINICAL CENTER · PI MARINCOLA, FRANCESCO M · 2009 to 2012
$0k
Immunogenetics of Vaccine TherapyZ01CL002115 · CLC · CLINICAL CENTER · PI MARINCOLA, FRANCESCO M · 2003 to 2005
–
6 · The paper itself

Abstract

The International Society for the Biological Therapy of Cancer (iSBTc) has initiated in collaboration with the United States Food and Drug Administration (FDA) a programmatic look at innovative avenues for the identification of relevant parameters to assist clinical and basic scientists who study the natural course of host/tumor interactions or their response to immune manipulation. The task force has two primary goals: 1) identify best practices of standardized and validated immune monitoring procedures and assays to promote inter-trial comparisons and 2) develop strategies for the identification of novel biomarkers that may enhance our understating of principles governing human cancer immune biology and, consequently, implement their clinical application. Two working groups were created that will report the developed best practices at an NCI/FDA/iSBTc sponsored workshop tied to the annual meeting of the iSBTc to be held in Washington DC in the Fall of 2009. This foreword provides an overview of the task force and invites feedback from readers that might be incorporated in the discussions and in the final document.

Indexed as

BiomarkersImmunotherapyResearchClinical Trials as TopicEducationHumansNeoplasmsReproducibility of ResultsResearch DesignUnited StatesUnited States Food and Drug AdministrationBiomarkers

Identifiers

PMID19105846
PMCPMC2630944
OpenAlexW2019527035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.