ArticleBMC genomics2008
Sequence divergence of Mus spretus and Mus musculus across a skin cancer susceptibility locus.
Article in BMC genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- High-quality mouse reference genomes reveal the structural complexity of the murine protein-coding landscape.Cell genomics · 2026Article
- Early reactivation of clustered genes on the inactive X chromosome during somatic cell reprogramming.Stem cell reports · 2022Article
- Phylogenetic relationship and time of divergence of Mus terricolor with reference to other Mus species.Journal of genetics · 2016Article
- Variants in an Hdac9 intronic enhancer plasmid impact Twist1 expression in vitro.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Article
- Global gene expression profiling using heterologous DNA microarrays to analyze alterations in the transcriptome of Mus spretus mice living in a heavily polluted environment.Environmental science and pollution research international · 2016Article
- Allele-specific imbalance mapping identifies HDAC9 as a candidate gene for cutaneous squamous cell carcinoma.International journal of cancer · 2014Article
- The impact of 3'UTR variants on differential expression of candidate cancer susceptibility genes.PloS one · 2013Article
- Article
- Mice lacking hepatic lipase are lean and protected against diet-induced obesity and hepatic steatosis.Endocrinology · 2010Article
- Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications.Nature protocols · 2009Article
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundMus spretus diverged from Mus musculus over one million years ago. These mice are genetically and phenotypically divergent. Despite the value of utilizing M. musculus and M. spretus for quantitative trait locus (QTL) mapping, relatively little genomic information on M. spretus exists, and most of the available sequence and polymorphic data is for one strain of M. spretus, Spret/Ei. In previous work, we mapped fifteen loci for skin cancer susceptibility using four different M. spretus by M. musculus F1 backcrosses. One locus, skin tumor susceptibility 5 (Skts5) on chromosome 12, shows strong linkage in one cross.
resultsTo identify potential candidate genes for Skts5, we sequenced 65 named and unnamed genes and coding elements mapping to the peak linkage area in outbred spretus, Spret/EiJ, FVB/NJ, and NIH/Ola. We identified polymorphisms in 62 of 65 genes including 122 amino acid substitutions. To look for polymorphisms consistent with the linkage data, we sequenced exons with amino acid polymorphisms in two additional M. spretus strains and one additional M. musculus strain generating 40.1 kb of sequence data. Eight candidate variants were identified that fit with the linkage data. To determine the degree of variation across M. spretus, we conducted phylogenetic analyses. The relatedness of the M. spretus strains at this locus is consistent with the proximity of region of ascertainment of the ancestral mice.
conclusionOur analyses suggest that, if Skts5 on chromosome 12 is representative of other regions in the genome, then published genomic data for Spret/EiJ are likely to be of high utility for genomic studies in other M. spretus strains.
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