ArticleBMC cardiovascular disorders2008
Association of alpha1a-adrenergic receptor polymorphism and blood pressure phenotypes in the Brazilian population.
Article in BMC cardiovascular disorders, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Polygenic risk scores predict blood pressure changes independent of dietary intervention: a secondary analysis of the NUPRESS trial.European journal of nutrition · 2026Trial
- Vascular Reactions of the Diving Reflex in Men and Women Carrying Different ADRA1A Genotypes.International journal of molecular sciences · 2022Article
- Influence of Receptor Polymorphisms on the Response to α-Adrenergic Receptor Blockers in Pheochromocytoma Patients.Biomedicines · 2022Article
- Adrenergic receptors gene polymorphisms and autonomic nervous control of heart and vascular tone.Physiological research · 2021Review
- Chiropractic care for hypertension: Review of the literature and study of biological and genetic bases.Acta bio-medica : Atenei Parmensis · 2020Review
- GWAS on Imputed Whole-Genome Resequencing From Genotyping-by-Sequencing Data for Farrowing Interval of Different Parities in Pigs.Frontiers in genetics · 2019Article
- Genetic associations of bradykinin type 2 receptor, alpha-adrenoceptors and endothelial nitric oxide synthase with blood pressure and left ventricular mass in outpatients without overt heart disease.International journal of cardiology. Heart & vasculature · 2018Article
- Clinical significance of expression levels of serum ADRA1A in hysterocarcinoma patients.Oncology letters · 2018Article
- Preliminary evidence for a role of the adrenergic nervous system in generalized anxiety disorder.Scientific reports · 2017Article
- Genetic variation in the α1A-adrenergic receptor and phenylephrine-mediated venoconstriction.The pharmacogenomics journal · 2015Article
- Associations of carotid artery plaque with lower urinary tract symptoms and erectile dysfunction.International urology and nephrology · 2014Article
- Alpha-adrenergic receptor gene polymorphisms and cardiovascular reactivity to stress in Black adolescents and young adults.Psychophysiology · 2012Article
- Between candidate genes and whole genomes: time for alternative approaches in blood pressure genetics.Current hypertension reports · 2012Review
- Constitutive coupling of a naturally occurring human alpha1a-adrenergic receptor genetic variant to EGFR transactivation pathway.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- APOE polymorphism is associated with lipid profile, but not with arterial stiffness in the general population.Lipids in health and disease · 2010Article
- Synopsis and data synthesis of genetic association studies in hypertension for the adrenergic receptor family genes: the CUMAGAS-HYPERT database.American journal of hypertension · 2010Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe alpha1A-adrenergic receptor (alpha1A-AR) regulates the cardiac and peripheral vascular system through sympathetic activation. Due to its important role in the regulation of vascular tone and blood pressure, we aimed to investigate the association between the Arg347Cys polymorphism in the alpha1A-AR gene and blood pressure phenotypes, in a large sample of Brazilians from an urban population.
methodsA total of 1568 individuals were randomly selected from the general population of the Vitória City metropolitan area. Genetic analysis of the Arg347Cys polymorphism was conducted by polymerase chain reaction/restriction fragment length polymorphism. We have compared cardiovascular risk variables and genotypes using ANOVA, and Chi-square test for univariate comparisons and logistic regression for multivariate comparisons.
resultsAssociation analysis indicated a significant difference between genotype groups with respect to diastolic blood pressure (p = 0.04), but not systolic blood pressure (p = 0.12). In addition, presence of the Cys/Cys genotype was marginally associated with hypertension in our population (p = 0.06). Significant interaction effects were observed between the studied genetic variant, age and physical activity. Presence of the Cys/Cys genotype was associated with hypertension only in individuals with regular physical activity (odds ratio = 1.86; p = 0.03) or younger than 45 years (odds ratio = 1.27; p = 0.04).
conclusionPhysical activity and age may potentially play a role by disclosing the effects of the Cys allele on blood pressure. According to our data it is possible that the Arg347Cys polymorphism can be used as a biomarker to disease risk in a selected group of individuals.
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