ArticleJournal of combinatorial chemistry
Distributed Drug Discovery, Part 3: using D(3) methodology to synthesize analogs of an anti-melanoma compound.
Article in Journal of combinatorial chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Fluorophenylalanine-Containing Dipeptides with Antibiofilm Activity AgainstMolecules (Basel, Switzerland) · 2026Article
- BINANA 2: Characterizing Receptor/Ligand Interactions in Python and JavaScript.Journal of chemical information and modeling · 2022Article
- Multi-Institution Research and Education Collaboration Identifies New Antimicrobial Compounds.ACS chemical biology · 2020Article
- Gypsum-DL: an open-source program for preparing small-molecule libraries for structure-based virtual screening.Journal of cheminformatics · 2019Article
- Peptoids advance multidisciplinary research and undergraduate education in parallel: Sequence effects on conformation and lipid interactions.Biopolymers · 2019Article
- Documenting and harnessing the biological potential of molecules in Distributed Drug Discovery (D3) virtual catalogs.Chemical biology & drug design · 2017Article
- Solid-Phase Synthesis of Amine/Carboxyl Substituted Prolines and Proline Homologues: Scope and Limitations.Molecules (Basel, Switzerland) · 2016Article
- WebChem Viewer: a tool for the easy dissemination of chemical and structural data sets.BMC bioinformatics · 2014Article
- Unexpected hydrolytic instability of N-acylated amino acid amides and peptides.The Journal of organic chemistry · 2014Article
- Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.Journal of combinatorial chemistry · 2010Review
- Solid-phase synthetic route to multiple derivatives of a fundamental peptide unit.Molecules (Basel, Switzerland) · 2010Article
- Distributed Drug Discovery, Part 1: linking academia and combinatorial chemistry to find drug leads for developing world diseases.Journal of combinatorial chemistryArticle
- Distributed Drug Discovery, Part 2: global rehearsal of alkylating agents for the synthesis of resin-bound unnatural amino acids and virtual D(3) catalog construction.Journal of combinatorial chemistryArticle
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Authors and funding
11 authors.
Funding
Abstract
For the successful implementation of Distributed Drug Discovery (D(3)) (outlined in the accompanying Perspective), students, in the course of their educational laboratories, must be able to reproducibly make new, high quality, molecules with potential for biological activity. This article reports the successful achievement of this goal. Using previously rehearsed alkylating agents, students in a second semester organic chemistry laboratory performed a solid-phase combinatorial chemistry experiment in which they made 38 new analogs of the most potent member of a class of antimelanoma compounds. All compounds were made in duplicate, purified by silica gel chromatography, and characterized by NMR and LC/MS. As a continuing part of the Distributed Drug Discovery program, a virtual D(3) catalog based on this work was then enumerated and is made freely available to the global scientific community.
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