ArticleMolecular and cellular biochemistry2009
Liver fatty acid binding protein gene ablation enhances age-dependent weight gain in male mice.
Article in Molecular and cellular biochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Mechanistic studies of PEG-asparaginase-induced liver injury and hepatic steatosis in mice.Acta pharmaceutica Sinica. B · 2021Article
- Effect of liver fatty acid binding protein (L-FABP) gene ablation on lipid metabolism in high glucose diet (HGD) pair-fed mice.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2019Article
- Expression profile analysis of 5-day-old neonatal piglets infected with porcine Deltacoronavirus.BMC veterinary research · 2019Article
- Ablating both Fabp1 and Scp2/Scpx (TKO) induces hepatic phospholipid and cholesterol accumulation in high fat-fed mice.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2018Article
- Loss of fatty acid binding protein-1 alters the hepatic endocannabinoid system response to a high-fat diet.Journal of lipid research · 2017Article
- Female Mice are Resistant to Fabp1 Gene Ablation-Induced Alterations in Brain Endocannabinoid Levels.Lipids · 2016Article
- FABP-1 gene ablation impacts brain endocannabinoid system in male mice.Journal of neurochemistry · 2016Article
- IL-33 treatment attenuated diet-induced hepatic steatosis but aggravated hepatic fibrosis.Oncotarget · 2016Article
- Review
- Recent insights into the biological functions of liver fatty acid binding protein 1.Journal of lipid research · 2015Review
- Phenotypic divergence in two lines of L-Fabp-/- mice reflects substrain differences and environmental modifiers.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- Enterocyte fatty acid-binding proteins (FABPs): different functions of liver and intestinal FABPs in the intestine.Prostaglandins, leukotrienes, and essential fatty acids · 2015Review
- Human FABP1 T94A variant impacts fatty acid metabolism and PPAR-α activation in cultured human female hepatocytes.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Direct comparison of mice null for liver or intestinal fatty acid-binding proteins reveals highly divergent phenotypic responses to high fat feeding.The Journal of biological chemistry · 2013Article
- Impact of L-FABP and glucose on polyunsaturated fatty acid induction of PPARα-regulated β-oxidative enzymes.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- Loss of intracellular lipid binding proteins differentially impacts saturated fatty acid uptake and nuclear targeting in mouse hepatocytes.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- The effect of cocoa supplementation on hepatic steatosis, reactive oxygen species and LFABP in a rat model of NASH.Comparative hepatology · 2011Article
- Different functions of intestinal and liver-type fatty acid-binding proteins in intestine and in whole body energy homeostasis.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Computational prediction and experimental validation associating FABP-1 and pancreatic adenocarcinoma with diabetes.BMC gastroenterology · 2011Article
- Liver fatty acid-binding protein and obesity.The Journal of nutritional biochemistry · 2010Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Although studies performed in vitro and with transfected cells in culture suggest a role for liver fatty acid binding protein (L-FABP) in regulating fatty acid oxidation and fat deposition, the physiological significance of this possibility is not completely clear. To begin to address this question, the effect of L-FABP gene ablation on phenotype of standard rodent chow-fed male mice was examined with increasing age up to 18 months. While young (2-3 months old) L-FABP null mice displayed no visually obvious phenotype, with increasing age >9 months the L-FABP null mice were visibly larger, exhibiting increased body weight due to increased fat and lean tissue mass. Liver lipid concentrations were unaffected by L-FABP gene ablation with the exception of triacylglycerol, which was decreased by 74% in the livers of 3-month-old mice. Likewise, serum lipid levels were not altered in L-FABP null mice with the exception of triacylglycerol, which was increased in the serum of 18-month-old mice. Increased body weight, fat tissue mass, and lean tissue mass in 18-month-old L-FABP null mice were accompanied by increased hepatic levels of low-density lipoprotein (LDL) receptor, peroxisome proliferator-activated receptor (PPAR) alpha, and PPARalpha-regulated proteins such as fatty acid transport protein (FATP), fatty acid translocase (FAT/CD36), carnitine palmitoyl transferase I (CPT I), and lipoprotein lipase (LPL). A key enzyme in cholesterol biosynthesis, 3-hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) reductase, was down-regulated in L-FABP null mice. These findings were consistent with a proposed role for L-FABP as an important physiological regulator of PPARalpha.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.