ArticleImmunogenetics2009
Evolutionary history of an MHC gene in two leporid species: characterisation of Mhc-DQA in the European brown hare and comparison with the European rabbit.
Article in Immunogenetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Patterns of evolution in MHC class II DQA and DQB exon 2 genes of Alpine mountain hares, Lepus timidus varronis, and sympatric and parapatric brown hares, L. europaeus, from Switzerland.Immunogenetics · 2024Article
- Hybridization with mountain hares increases the functional allelic repertoire in brown hares.Scientific reports · 2021Article
- Purifying selection shaping the evolution of the Toll-like receptor 2 TIR domain in brown hares (Lepus europaeus) from Europe and the Middle East.Molecular biology reports · 2020Article
- Comparative analysis of host resistance to Sarcoptes scabiei var. cuniculi in two different rabbit breeds.Parasites & vectors · 2019Article
- Positive selection and climatic effects on MHC class II gene diversity in hares (Lepus capensis) from a steep ecological gradient.Scientific reports · 2018Article
- Spatial pattern of genetic diversity and selection in the MHC class II DRB of three Neotropical bat species.BMC evolutionary biology · 2016Article
- Evolutionary study of leporid CD4 reveals a hotspot of genetic variability within the D2 domain.Immunogenetics · 2016Article
- Genetic diversity comparison of the DQA gene in European rabbit (Oryctolagus cuniculus) populations.Immunogenetics · 2015Article
- Genetic variation in the major histocompatibility complex of the European brown hare (Lepus europaeus) across distinct phylogeographic areas.Immunogenetics · 2014Article
- Evolution of viral sensing RIG-I-like receptor genes in Leporidae genera Oryctolagus, Sylvilagus, and Lepus.Immunogenetics · 2014Article
- Swine Leukocyte Antigen-DQA Gene Variation and Its Association with Piglet Diarrhea in Large White, Landrace and Duroc.Asian-Australasian journal of animal sciences · 2013Article
- MHC class IIB exon 2 polymorphism in the Grey partridge (Perdix perdix) is shaped by selection, recombination and gene conversion.PloS one · 2013Article
- Independent evolution of functional MHC class II DRB genes in New World bat species.Immunogenetics · 2012Article
- Evidence for evolutionary convergence at MHC in two broadly distributed mesocarnivores.Immunogenetics · 2012Article
- MHC class II genes in the European badger (Meles meles): characterization, patterns of variation, and transcription analysis.Immunogenetics · 2012Article
- Sex-specific selection for MHC variability in Alpine chamois.BMC evolutionary biology · 2012Article
- Evolutionary genetics of MHC class II beta genes in the brown hare, Lepus europaeus.Immunogenetics · 2011Article
- Polymorphism and signatures of selection in the multimammate rat DQB gene.Immunogenetics · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We surveyed the genetic diversity of the expressed major histocompatibility complex class II DQA locus in natural populations of European brown hares, Lepus europaeus, from Austria and Belgium (267 individuals in total). Based on cDNA sequences, we designed hare-specific primers to amplify the highly variable second exon of the DQA gene. Using cloning-sequencing methodology and capillary electrophoresis single-strand conformation polymorphism, we found ten alleles of the DQA exon 2 locus across these two European regions, of which eight are described for the first time. To search for signals of selection and recombination in the evolution of the DQA gene within the leporids, we augmented our sample with orthologous DQA alleles from the European rabbit, Oryctolagus cuniculus, in order to carry out a species level, species pairwise comparison. We found evidence of recombination in the history of the DQA sequences in leporids with some recombinant alleles bridging the species divide. In both species, selection on peptide binding site codons can be detected, though stronger for the rabbit. This result suggests that there may be a differential selection pressure in the deeper evolutionary history of these two species due to differences in several demographic and ecological traits likely subjecting them to differential selection by parasites. Finally, evolutionary relationships show a widespread and statistically significant intermingling of alleles from the two species. The many macroparasites shared between hares and rabbits may explain this pattern of trans-species polymorphism.
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