ArticleOptometry and vision science : official publication of the American Academy of Optometry2009
Molecular genetics of human myopia: an update.
Article in Optometry and vision science : official publication of the American Academy of Optometry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01269697 (Lutein Influence on Macula of Persons Issued From Amd Parents), which is not on this map. Cited by 44 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lutein Influence on Macula of Persons Issued From Amd Parents
Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A Review of Current Concepts of the Etiology and Treatment of Myopia.Eye & contact lens · 2018Pooled it
- Polymorphism in the 11q24.1 genomic region is associated with myopia: a comprehensive genetic study in Chinese and Japanese populations.Molecular vision · 2014Pooled it
- Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium.Human genetics · 2012Pooled it
- Aquaporin-1 upregulation is associated with scleral remodeling during myopia development in mice.American journal of translational research · 2026Article
- Ocular biological parameters and prevalence of myopia in vocational high school and general high school in China.Frontiers in public health · 2023Article
- Ocular elongation and retraction in foveated reptiles.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- Functional integration of eye tissues and refractive eye development: Mechanisms and pathways.Experimental eye research · 2021Review
- Article
- Identification and Functional Characterization of a Novel Nonsense Variant inFrontiers in genetics · 2021Article
- MYP2 locus genes: Sequence variations, genetic association studies and haplotypic association in patients with High Myopia.International journal of biochemistry and molecular biology · 2021Article
- Differential Regional Stiffening of Sclera by Collagen Cross-linking.Current eye research · 2020Article
- Myopia progression varies with age and severity of myopia.PloS one · 2020Article
- Imbalance Between Oxidative Stress and Growth Factors in Human High Myopia.Frontiers in physiology · 2020Article
- Analysis of genetic networks regulating refractive eye development in collaborative cross progenitor strain mice reveals new genes and pathways underlying human myopia.BMC medical genomics · 2019Article
- Epigenetically dysregulated genes and pathways implicated in the pathogenesis of non-syndromic high myopia.Scientific reports · 2019Article
- IMI - Report on Experimental Models of Emmetropization and Myopia.Investigative ophthalmology & visual science · 2019Review
- Genes and genetics in eye diseases: a genomic medicine approach for investigating hereditary and inflammatory ocular disorders.International journal of ophthalmology · 2018Review
- Assessing the Genetic Predisposition of Education on Myopia: A Mendelian Randomization Study.Genetic epidemiology · 2016Article
- Myopia in schoolchildren in a rural community in the State of Mexico, Mexico.Clinical optometry · 2016Article
- Topical Atropine in the Control of Myopia.Medical hypothesis, discovery & innovation ophthalmology journal · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Myopia, or nearsightedness, is the most common human eye disorder in the world, and is a significant global public health concern. Along with cataract, macular degeneration, infectious disease, and vitamin A deficiency, myopia is one of the most important causes of visual impairment worldwide. Severe or high-grade myopia is a leading cause of blindness because of its associated ocular morbidities of retinal detachment, macular choroidal degeneration, premature cataract, and glaucoma. Ample evidence documents the heritability of the non-syndromic forms of this condition, especially for high-grade myopia, commonly referred to as myopic spherical refractive power of 5 to 6 diopters or higher. Multiple high-grade myopia genetic loci have been identified, and confirmatory studies identifying high-grade and moderate myopia loci have also occurred. In general, myopia susceptibility genes are unknown with few association studies performed, and without confirmation in other research laboratories or testing of separate patient cohorts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.