ArticleObstetrics and gynecology2009
Prediction of treatment outcomes after global endometrial ablation.
Article in Obstetrics and gynecology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Ultrasound Appearance of the Endometrium Post Radio-Frequency Ablation
Clinical Predictive Factors of Success of Hysteroscopic Endometrial Ablation/Resection; Retrospective Study at a Tertiary University Hospital
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 154 citations in OpenAlex.
- Pre-operative endometrial thinning agents before endometrial destruction for heavy menstrual bleeding.The Cochrane database of systematic reviews · 2013Pooled it
- Water Vapor Endometrial Ablation for Heavy Menstrual Bleeding: 36-Month Follow-Up of a Prospective, Multicenter Pivotal Clinical Trial.International journal of women's health · 2021Trial
- Recurrent Hematocolpos and Hematometra as a Late Complication of Endometrial Ablation: A Case Report.Cureus · 2025Article
- Hysterectomy Rate Following Endometrial Ablation in Ontario: A Cohort Analysis of 76,446 Patients.Facts, views & vision in ObGyn · 2024Article
- Clinical analysis of 2152 cases of abnormal uterine bleeding treated by NovaSure endometrial ablation.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2022Article
- Pathological findings in the endometrium after microwave endometrial ablation.Scientific reports · 2020Article
- Late-onset endometrial ablation failure.Case reports in women's health · 2017Review
- Article
- Incidence and predictors of failed second-generation endometrial ablation.Gynecological surgery · 2017Article
- Ambulatory management of heavy menstrual bleeding.Women's health (London, England) · 2016Review
- Endometrial ablation for heavy menstrual bleeding.Women's health (London, England) · 2016Review
- Cost-Effectiveness of Global Endometrial Ablation vs. Hysterectomy for Treatment of Abnormal Uterine Bleeding: US Commercial and Medicaid Payer Perspectives.Population health management · 2015Article
- Cost effectiveness of endometrial ablation with the NovaSure(®) system versus other global ablation modalities and hysterectomy for treatment of abnormal uterine bleeding: US commercial and Medicaid payer perspectives.International journal of women's health · 2015Article
- Adenomyosis: Epidemiology, Risk Factors, Clinical Phenotype and Surgical and Interventional Alternatives to Hysterectomy.Geburtshilfe und Frauenheilkunde · 2013Article
- Challenges in the gynecologic care of premenopausal women with breast cancer.Mayo Clinic proceedings · 2011Review
- Uterine leiomyomas: individualizing the approach to a heterogeneous condition.Obstetrics and gynecology · 2011Review
- Thermal balloon endometrial ablation in dysfunctional uterine bleeding.Journal of gynecological endoscopy and surgery · 2009Article
- Efficacy of bipolar radiofrequency endometrial ablation vs thermal balloon ablation for management of menorrhagia: A population-based cohort.Journal of minimally invasive gynecologyArticle
- Characteristics of patients undergoing hysterectomy for failed endometrial ablation.JSLS : Journal of the Society of Laparoendoscopic SurgeonsArticle
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo report rates of amenorrhea and treatment failure after global endometrial ablation and to estimate the association between patient factors and these outcomes by developing and validating prediction models.
methodsFrom January 1998 through December 2005, 816 women underwent global endometrial ablation with either a thermal balloon ablation or radio frequency ablation device; 455 were included in a population-derived cohort (for model development), and 361 were included in a referral-derived cohort (for model validation). Amenorrhea was defined as cessation of bleeding from immediately after ablation through at least 12 months after the procedure. Treatment failure was defined as hysterectomy or reablation for patients with bleeding or pain. Logistic and Cox proportional hazard regression models were used in model development and validation of potential predictors of outcomes.
resultsThe amenorrhea rate was 23% (95% confidence interval [CI] 19-28%) and the 5-year cumulative failure rate was 16% (95% CI 10-20%). Predictors of amenorrhea were age 45 years or older (adjusted odds ratio [aOR] 2.6, 95% CI 1.6-4.3); uterine length less than 9 cm (aOR 1.8, 95% CI 1.1-3.1); endometrial thickness less than 4 mm (aOR 2.7, 95% CI 1.2-6.3); and use of radio-frequency ablation instead of thermal balloon ablation (aOR 2.8, 95% CI 1.7-4.9). Predictors of treatment failure included age younger than 45 years (adjusted hazard ratio [aHR] 2.6, 95% CI 1.3-5.1); parity of 5 or greater (aHR 6.0, 95% CI 2.5-14.8); prior tubal ligation (aHR 2.2, 95% CI 1.2-4.0); and history of dysmenorrhea (aHR 3.7, 95% CI 1.6-8.5). After global endometrial ablation, 23 women (5.1%, 95% CI 3.2-7.5%) had pelvic pain, three (0.7%, 95% CI 0.1-1.9%) were pregnant, and none (95% CI 0-0.8%) had endometrial cancer.
conclusionPopulation-derived rates and predictors of treatment outcomes after global endometrial ablation may help physicians offer optimal preprocedural patient counseling. LEVEL OF EVIDENCE: II.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.