ReviewCurrent opinion in endocrinology, diabetes, and obesity2009
Peptide processing and biology in human disease.
Review in Current opinion in endocrinology, diabetes, and obesity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Article
- Relationship betweenWorld journal of gastrointestinal surgery · 2024Article
- Mapping prohormone processing by proteases in human enteroendocrine cells using genetically engineered organoid models.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Cell cycle dependent expression of the CCK2 receptor by gastrointestinal myofibroblasts: putative role in determining cell migration.Physiological reports · 2017Article
- Spinal astrocytes produce and secrete dynorphin neuropeptides.Neuropeptides · 2013Article
- Progastrin Peptides Increase the Risk of Developing Colonic Tumors: Impact on Colonic Stem Cells.Current colorectal cancer reports · 2012Article
- A mass spectrometry-based method to screen for α-amidated peptides.Proteomics · 2012Article
- Gastrins, iron homeostasis and colorectal cancer.Biochimica et biophysica acta · 2011Review
- Feeding regulates the expression of pancreatic genes in gastric mucosa.Journal of obesity · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewTo describe recent advances in the processing of gastrointestinal hormones, and the consequences for human disease of mutations in the enzymes involved. RECENT
findingsAlthough gastrointestinal prohormones were long regarded as devoid of biological activity, recent data indicate that the prohormones for both gastrin and gastrin-releasing peptide are bioactive, through different receptors from the mature hormones. Mutations in the family of prohormone convertases responsible for the initial steps in the processing of gastrointestinal hormones are associated with several different pathophysiological conditions in humans. SUMMARY: Human mutational studies, when taken together with the phenotypes observed in mice deficient in the prohormone convertases, emphasize the crucial importance of the processing enzymes in mammalian biology. Although the phenotypes may often be ascribed to defective production of a mature hormone or growth factor, the recognition that the precursors are independently bioactive suggests that the increased precursor concentrations may also contribute to the symptoms. The observation that the precursors often act through different receptors from the mature hormones may permit the development of precursor-selective antagonists for therapeutic use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.