Evidence map›Paper›PMID 19104079›Full record

ArticleGenetics2009

Characterization of chromosome ends in the filamentous fungus Neurospora crassa.

Cheng Wu, Yun-Sik Kim, Kristina M Smith, Weixi Li, Heather M Hood, Chuck Staben, Eric U Selker, Matthew S Sachs, Mark L Farman

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
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  4. Article
  5. Chromosome-level analysis of theFrontiers in microbiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Cheng WuDepartment of Environmental and Biomolecular Systems, Oregon Health and Science University, Beaverton, Oregon 97006, USA.
Yun-Sik Kim
Kristina M Smith
Weixi Li
Heather M Hood
Chuck Staben
Eric U Selker
Matthew S Sachs
Mark L Farman
University of Kentucky · USOregon Health & Science University · USUniversity of Oregon · US

Funding

ZEBRAFISH VISUAL FUNCTION RECOVERY FOLLOWING OPTIC NERVE DAMAGEP20RR016481 · NCRR · UNIVERSITY OF LOUISVILLE · PI BARTON, HAZEL A · 2001 to 2011
$34.8M
Tools for Functional Analysis and Cell BiologyP01GM068087 · NIGMS · DARTMOUTH COLLEGE · PI DUNLAP, JAY C. · 2004 to 2013
$19.3M
NCRR NIH HHS 5P20RR016481-03NCRR NIH HHS P20 RR016481NIGMS NIH HHS GM068087NIGMS NIH HHS P01 GM068087
6 · The paper itself

Abstract

Telomeres and subtelomere regions have vital roles in cellular homeostasis and can facilitate niche adaptation. However, information on telomere/subtelomere structure is still limited to a small number of organisms. Prior to initiation of this project, the Neurospora crassa genome assembly contained only 3 of the 14 telomeres. The missing telomeres were identified through bioinformatic mining of raw sequence data from the genome project and from clones in new cosmid and plasmid libraries. Their chromosomal locations were assigned on the basis of paired-end read information and/or by RFLP mapping. One telomere is attached to the ribosomal repeat array. The remaining chromosome ends have atypical structures in that they lack distinct subtelomere domains or other sequence features that are associated with telomeres in other organisms. Many of the chromosome ends terminate in highly AT-rich sequences that appear to be products of repeat-induced point mutation, although most are not currently repeated sequences. Several chromosome termini in the standard Oak Ridge wild-type strain were compared to their counterparts in an exotic wild type, Mauriceville. This revealed that the sequences immediately adjacent to the telomeres are usually genome specific. Finally, despite the absence of many features typically found in the telomere regions of other organisms, the Neurospora chromosome termini still retain the dynamic nature that is characteristic of chromosome ends.

Indexed as

Base CompositionChromosomes, FungalCloning, MolecularCosmidsDatabases, GeneticDNA Restriction EnzymesGenes, FungalGenetic LinkageMolecular Sequence DataNeurospora crassaNucleotidesPolymorphism, Restriction Fragment LengthRepetitive Sequences, Nucleic AcidSoftwareSpecies SpecificitySystems BiologyDNA Restriction EnzymesNucleotides

Identifiers

PMID19104079
PMCPMC2651048
OpenAlexW2153082917

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.