ArticleProceedings of the National Academy of Sciences of the United States of America2008
Redundant mechanisms mediate bristle patterning on the Drosophila thorax.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Exposome variations affect Drosophila bristle patterning via the regulation of proneural genes through distinct mechanisms.Scientific reports · 2025Article
- Buffered EGFR signaling regulated by spitz-to-argos expression ratio is a critical factor for patterning the Drosophila eye.PLoS genetics · 2023Article
- Evolution and genomic basis of the plant-penetrating ovipositor: a key morphological trait in herbivorous Drosophilidae.Proceedings. Biological sciences · 2022Article
- "A fly appeared": sable, a classic Drosophila mutation, maps to Yippee, a gene affecting body color, wings, and bristles.G3 (Bethesda, Md.) · 2022Article
- The wing imaginal disc.Genetics · 2022Article
- A cell atlas of adult muscle precursors uncovers early events in fibre-type divergence in Drosophila.EMBO reports · 2020Article
- Regulation of theeLife · 2018Article
- Nymphalid eyespots are co-opted to novel wing locations following a similar pattern in independent lineages.BMC evolutionary biology · 2015Article
- The bristle patterning genes hairy and extramacrochaetae regulate the development of structures required for flight in Diptera.Developmental biology · 2014Article
- Essential roles of Da transactivation domains in neurogenesis and in E(spl)-mediated repression.Molecular and cellular biology · 2012Article
- The kinase Sgg modulates temporal development of macrochaetes in Drosophila by phosphorylation of Scute and Pannier.Development (Cambridge, England) · 2012Article
- Properties of developmental gene regulatory networks.Proceedings of the National Academy of Sciences of the United States of America · 2008Review
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4 authors.
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Abstract
The thoracic bristle pattern of Drosophila results from the spatially restricted expression of the achaete-scute (ac-sc) genes in clusters of cells, mediated by the activity of many discrete cis-regulatory sequences. However, ubiquitous expression of sc or asense (ase) achieved with a heterologous promoter, in the absence of endogenous ac-sc expression, and the activity of the cis-regulatory elements, allows the development of bristles positioned at wild-type locations. We demonstrate that the products of the genes stripe, hairy, and extramacrochaetae contribute to rescue by antagonizing the activity of Sc and Ase. The three genes are expressed in specific but overlapping spatial domains of expression that form a prepattern that allows precise positioning of bristles. The redundant mechanisms might contribute to the robustness of the pattern. We discuss the possibility that patterning in trans by antagonism is ancestral and that the positional cis-regulatory sequences might be of recent origin.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.