ArticleProceedings of the National Academy of Sciences of the United States of America2008
The Caenorhabditis elegans vulva: a post-embryonic gene regulatory network controlling organogenesis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Regulation of hlh-2 transcription during specification of the anchor cell of the C. elegans hermaphrodite gonad.G3 (Bethesda, Md.) · 2026Article
- A neural network-based model framework for cell-fate decisions and development.Communications biology · 2024Article
- Article
- Genetic factors in methylmercury-induced neurotoxicity: What have we learned fromAdvances in neurotoxicology · 2023Article
- Identifying the Caenorhabditis elegans vulval transcriptome.G3 (Bethesda, Md.) · 2022Article
- Article
- Encounters across networks: Windows into principles of genomic regulation.Marine genomics · 2019Article
- The Signaling Network Controlling C. elegans Vulval Cell Fate Patterning.Journal of developmental biology · 2018Review
- Review
- Morphologically defined sub-stages of C. elegans vulval development in the fourth larval stage.BMC developmental biology · 2015Article
- Multicolor labeling in developmental gene regulatory network analysis.Methods in molecular biology (Clifton, N.J.) · 2014Article
- Quantitative analysis of cytokinesis in situ during C. elegans postembryonic development.PloS one · 2014Article
- Article
- The transcription factor HLH-2/E/Daughterless regulates anchor cell invasion across basement membrane in C. elegans.Developmental biology · 2011Article
- Review
- Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network.Molecular systems biology · 2010Article
- C. elegans BED domain transcription factor BED-3 controls lineage-specific cell proliferation during organogenesis.Developmental biology · 2010Article
- Properties of developmental gene regulatory networks.Proceedings of the National Academy of Sciences of the United States of America · 2008Review
- Morphogenesis of the caenorhabditis elegans vulva.Wiley interdisciplinary reviews. Developmental biologyReview
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The Caenorhabditis elegans vulva is an elegant model for dissecting a gene regulatory network (GRN) that directs postembryonic organogenesis. The mature vulva comprises seven cell types (vulA, vulB1, vulB2, vulC, vulD, vulE, and vulF), each with its own unique pattern of spatial and temporal gene expression. The mechanisms that specify these cell types in a precise spatial pattern are not well understood. Using reverse genetic screens, we identified novel components of the vulval GRN, including nhr-113 in vulA. Several transcription factors (lin-11, lin-29, cog-1, egl-38, and nhr-67) interact with each other and act in concert to regulate target gene expression in the diverse vulval cell types. For example, egl-38 (Pax2/5/8) stabilizes the vulF fate by positively regulating vulF characteristics and by inhibiting characteristics associated with the neighboring vulE cells. nhr-67 and egl-38 regulate cog-1, helping restrict its expression to vulE. Computational approaches have been successfully used to identify functional cis-regulatory motifs in the zmp-1 (zinc metalloproteinase) promoter. These results provide an overview of the regulatory network architecture for each vulval cell type.
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