ReviewThe Journal of biological chemistry2009
Structure-based ligand design and the promise held for antiprotozoan drug discovery.
Review in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 45 citations in OpenAlex.
- An Overview of Acridine Analogs: Pharmacological Significance and Recent Developments.Current medicinal chemistry · 2025Review
- Burkholderia pseudomallei d-alanine-d-alanine ligase; detailed characterisation and assessment of a potential antibiotic drug target.The FEBS journal · 2019Article
- The calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design.Parasitology · 2018Review
- An Improved Model of the Trypanosoma brucei CTP Synthetase Glutaminase Domain-Acivicin Complex.ChemMedChem · 2017Article
- Article
- Thermodynamic Proxies to Compensate for Biases in Drug Discovery Methods.Pharmaceutical research · 2016Article
- Structures of Pseudomonas aeruginosa β-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the crystal form.Acta crystallographica. Section F, Structural biology communications · 2015Article
- The structure of tubulin-binding cofactor A from Leishmania major infers a mode of association during the early stages of microtubule assembly.Acta crystallographica. Section F, Structural biology communications · 2015Article
- An alternative mechanism for the methylation of phosphoethanolamine catalyzed by Plasmodium falciparum phosphoethanolamine methyltransferase.The Journal of biological chemistry · 2014Article
- Combined docking, molecular dynamics simulations and spectroscopic studies for the rational design of a dipeptide ligand for affinity chromatography separation of human serum albumin.Journal of molecular modeling · 2014Article
- Nematode phospholipid metabolism: an example of closing the genome-structure-function circle.Trends in parasitology · 2014Review
- High-resolution structure of the M14-type cytosolic carboxypeptidase from Burkholderia cenocepacia refined exploiting PDB_REDO strategies.Acta crystallographica. Section D, Biological crystallography · 2014Article
- Two high-resolution structures of the human E3 ubiquitin ligase Siah1.Acta crystallographica. Section F, Structural biology and crystallization communications · 2013Article
- Structure of diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase from Acinetobacter baumannii.Acta crystallographica. Section F, Structural biology and crystallization communications · 2013Article
- Structure of Pseudomonas aeruginosa inosine 5'-monophosphate dehydrogenase.Acta crystallographica. Section F, Structural biology and crystallization communications · 2013Article
- The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery.Acta crystallographica. Section F, Structural biology and crystallization communications · 2013Article
- Acinetobacter baumannii FolD ligand complexes --potent inhibitors of folate metabolism and a re-evaluation of the structure of LY374571.The FEBS journal · 2012Article
- Structure of Leishmania major cysteine synthase.Acta crystallographica. Section F, Structural biology and crystallization communications · 2012Article
- The crystal structure of Leishmania major N(5),N(10)-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug target.Molecular and biochemical parasitology · 2012Article
- Structure and reaction mechanism of phosphoethanolamine methyltransferase from the malaria parasite Plasmodium falciparum: an antiparasitic drug target.The Journal of biological chemistry · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The development of the pharmaceutical industry, driven by progress in chemistry, biology, and technology, ranks as one of the most successful of human endeavors. However, serious health problems persist, among which are diseases caused by protozoan parasites, largely ignored in modern times. Advances in genomic sciences, molecular and structural biology, and computational and medicinal chemistry now set the scene for a renewed assault on such infections. A structure-centric approach to support discovery of antiparasitic compounds promises much. Current strategies and benefits of a structure-based approach to support early stage drug discovery will be described.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.