ArticleNeuroImage2009
Computerized assessment of vessel morphological changes during treatment of glioblastoma multiforme: report of a case imaged serially by MRA over four years.
Article in NeuroImage, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Exercise Test Performance Reveals Evidence of the Cardiorespiratory Fitness Hypothesis.Journal of aging and physical activity · 2017Trial
- Ultrasound imaging of breast tumor perfusion and neovascular morphology.Ultrasound in medicine & biology · 2015Trial
- Computational Fractal-Based Analysis of MR Susceptibility-Weighted Imaging (SWI) in Neuro-Oncology and Neurotraumatology.Advances in neurobiology · 2024Article
- Non-invasive transcranial volumetric ultrasound localization microscopy of the rat brain with continuous, high volume-rate acquisition.Theranostics · 2023Article
- Novel Radiomic Measurements of Tumor-Associated Vasculature Morphology on Clinical Imaging as a Biomarker of Treatment Response in Multiple Cancers.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022Article
- Characterization of an Array-Based Dual-Frequency Transducer for Superharmonic Contrast Imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Vascular amounts and dispersion of caliber-classified vessels as key parameters to quantitate 3D micro-angioarchitectures in multiple myeloma experimental tumors.Scientific reports · 2018Article
- Quantitative vessel tortuosity: A potential CT imaging biomarker for distinguishing lung granulomas from adenocarcinomas.Scientific reports · 2018Article
- Article
- Glioma vessel abnormality quantification using time-of-flight MR angiography.Magma (New York, N.Y.) · 2016Article
- Quantification of Microvascular Tortuosity during Tumor Evolution Using Acoustic Angiography.Ultrasound in medicine & biology · 2015Article
- Acoustic angiography: a new imaging modality for assessing microvasculature architecture.International journal of biomedical imaging · 2013Article
- Article
- Vascular tortuosity: a mathematical modeling perspective.The journal of physiological sciences : JPS · 2012Article
- Development of image-processing software for automatic segmentation of brain tumors in MR images.Journal of medical physics · 2011Article
- Algorithm-based method for detection of blood vessels in breast MRI for development of computer-aided diagnosis.Journal of magnetic resonance imaging : JMRI · 2009Article
- Current status and prospects for microbubbles in ultrasound theranostics.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
A patient with glioblastoma multiforme underwent serial computerized analysis of tumor-associated vasculature defined from magnetic resonance angiographic (MRA) scans obtained over almost a four year period. The clinical course included tumor resection with subsequent radiation therapy, a long symptom-free interval, emergence of a new malignant focus, resection of that focus, a stroke, and treatment with chemotherapy and anti-angiogenic therapy. Image analysis methods included segmentation of vessels from each MRA and statistical comparison of vessel morphology over 4 regions of interest (the initial tumor site, the second tumor site, a distant control region, and the entire brain) to the same 4 regions of interest in 50 healthy volunteers (26 females and 24 males; mean age 39 years). Results suggested that following completion of focal radiation therapy (RT) vessel shape abnormalities, if elevated at the time of RT completion, may progressively normalize for months in focal regions, that progressively severe vessel shape abnormalities can precede the emergence of a gadolinium enhancing lesion by months, that lesion resection can produce a dramatic but highly transient drop in abnormal vessel tortuosity both focally and globally, and that treatment with anti-angiogenic agents does not necessarily normalize vessel shape. Quantitative measurements of vessel morphology as defined from MRA may provide useful insights into tumor development and response to therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.