ArticleVirology journal2008
Identification of a novel picornavirus related to cosaviruses in a child with acute diarrhea.
Article in Virology journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 98 citations in OpenAlex.
- Article
- Longitudinal analysis of the enteric virome in paediatric subjects from the Free State Province, South Africa, reveals early gut colonisation and temporal dynamics.Virus research · 2024Article
- Gut virome in early life: origins and implications.Current opinion in virology · 2022Review
- Evolutionary Relationships of Ljungan Virus Variants Circulating in Multi-Host Systems across Europe.Viruses · 2021Article
- High viral load detection of human Cosavirus in Iranian pediatric patients with acute gastroenteritis.Gastroenterology and hepatology from bed to bench · 2021Article
- Article
- Viral species richness and composition in young children with loose or watery stool in Ethiopia.BMC infectious diseases · 2019Article
- Occurrence and Genetic Diversity of Human Cosavirus in Sewage in Italy.Food and environmental virology · 2018Article
- Complex virome in feces from Amerindian children in isolated Amazonian villages.Nature communications · 2018Article
- Near full length genome of a recombinant (E/D) cosavirus strain from a rural area in the central region of Brazil.Scientific reports · 2018Article
- A decade of RNA virus metagenomics is (not) enough.Virus research · 2018Review
- A novel type of cosavirus from children with nonpolio acute flaccid paralysis.Virology journal · 2016Article
- High diversity of picornaviruses in rats from different continents revealed by deep sequencing.Emerging microbes & infections · 2016Article
- Occurrence of Human Cosavirus in Wastewater and River Water in Japan.Food and environmental virology · 2014Article
- Unexplained diarrhoea in HIV-1 infected individuals.BMC infectious diseases · 2014Article
- Molecular detection of gastrointestinal viral infections in hospitalized patients.Diagnostic microbiology and infectious disease · 2013Article
- Persistent human cosavirus infection in lung transplant recipient, Italy.Emerging infectious diseases · 2013Article
- Diversity of picornaviruses in rural Bolivia.The Journal of general virology · 2013Article
- New strategy for virus discovery: viruses identified in human feces in the last decade.Science China. Life sciences · 2013Review
- The diversity of human RNA viruses.Future virology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Diarrhea, the third leading infectious cause of death worldwide, causes approximately 2 million deaths a year. Approximately 40% of these cases are of unknown etiology. We previously developed a metagenomic strategy for identification of novel viruses from diarrhea samples. By applying mass sequencing to a stool sample collected in Melbourne, Australia from a child with acute diarrhea, one 395 bp sequence read was identified that possessed only limited identity to known picornaviruses. This initial fragment shared only 55% amino acid identity to its top BLAST hit, the VP3 protein of Theiler's-like virus, suggesting that a novel picornavirus might be present in this sample. By using a combination of mass sequencing, RT-PCR, 5' RACE and 3' RACE, 6562 bp of the viral genome was sequenced, which includes the entire putative polyprotein. The overall genomic organization of this virus was similar to known picornaviruses. Phylogenetic analysis of the polyprotein demonstrated that the virus was divergent from previously described picornaviruses and appears to belong to the newly proposed picornavirus genus, Cosavirus. Based on the analysis discussed here, we propose that this virus represents a new species in the Cosavirus genus, and it has tentatively been named Human Cosavirus E1 (HCoSV-E1).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.