Trial reportBMC psychiatry2008
The effect of antipsychotic medication on sexual function and serum prolactin levels in community-treated schizophrenic patients: results from the Schizophrenia Trial of Aripiprazole (STAR) study (NCT00237913).
Trial report in BMC psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multicenter, Randomized, Naturalistic, Open-Label Study Between Aripiprazole and Standard of Care in the Management of Community-Treated Schizophrenic Patients (Schizophrenia Trial of Aripiprazole - STAR)
A Survey of Sexual Function in Schizophrenic Patients
An Open-label Study to Determine the Effect of Switching to Aripiprazole Once Monthly for Subjects With Schizophrenia Experiencing Worsening Sexual Dysfunction With Invega Sustenna or Risperdal Consta
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Management of sexual dysfunction due to antipsychotic drug therapy.The Cochrane database of systematic reviews · 2012Pooled it
- Bromperidol decanoate (depot) for schizophrenia.The Cochrane database of systematic reviews · 2012Pooled it
- Reduced sexual dysfunction with aripiprazole once-monthly versus paliperidone palmitate: results from QUALIFY.International clinical psychopharmacology · 2017Trial
- The atypical antipsychotics and sexual dysfunction: a pharmacovigilance-pharmacodynamic study.Frontiers in pharmacology · 2024Article
- Risperidone Induced Hyperprolactinemia: From Basic to Clinical Studies.Frontiers in psychiatry · 2022Review
- Olanzapine induced reproductive toxicity in male rats.Scientific reports · 2021Article
- Management Strategies for Antipsychotic-Related Sexual Dysfunction: A Clinical Approach.Journal of clinical medicine · 2021Review
- Assessment of sexual dysfunction and associated factors among patients with schizophrenia in Ethiopia, 2017.BMC psychiatry · 2018Article
- Effects of 2-bromoterguride, a dopamine DPsychopharmacology · 2018Article
- A Comparative Study of Short Term Efficacy of Aripiprazole and Risperidone in Schizophrenia.Current neuropharmacology · 2017Article
- Effects of long-term treatment with haloperidol, clozapine and aripiprazole on mice isolated vas deferens.International urology and nephrology · 2017Article
- Serum prolactin levels and sexual dysfunction in patients with schizophrenia treated with antipsychotics: comparison between aripiprazole and other atypical antipsychotics.Annals of general psychiatry · 2017Article
- Adjunctive aripiprazole in risperidone-induced hyperprolactinaemia: double-blind, randomised, placebo-controlled trial.BJPsych open · 2015Article
- Sexual dysfunction in outpatients with schizophrenia in Turkey: a cross-sectional study.Shanghai archives of psychiatry · 2014Article
- The effects of novel and newly approved antipsychotics on serum prolactin levels: a comprehensive review.CNS drugs · 2014Review
- Prolactin serum concentrations during aripiprazole treatment in youth.Journal of child and adolescent psychopharmacology · 2013Review
- Antipsychotic-induced sexual dysfunction and its management.The world journal of men's health · 2012Article
- An update on female sexual function and dysfunction in old age and its relevance to old age psychiatry.Aging and disease · 2012Article
- Review
- Retrospective study of Japanese patients with schizophrenia treated with aripiprazole.ISRN nursing · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this paper is to evaluate the effect of antipsychotics for the treatment of schizophrenia in a community based study on sexual function and prolactin levels comparing the use of aripiprazole and standard of care (SOC), which was a limited choice of three widely used and available antipsychotics (olanzapine, quetiapine or risperidone) (The Schizophrenia Trial of Aripiprazole [STAR] study [NCT00237913]).
methodThis open-label, 26-week, multi-centre, randomised study compared aripiprazole to SOC (olanzapine, quetiapine or risperidone) in patients with schizophrenia (DSM-IV-TR criteria). The primary effectiveness variable was the mean total score of the Investigator Assessment Questionnaire (IAQ) at Week 26. The outcome research variables included the Arizona Sexual Experience scale (ASEX). This along with the data collected on serum prolactin levels at week 4, 8, 12, 18 and 26 will be the focus of this paper.
resultsA total of 555 patients were randomised to receive aripiprazole (n = 284) or SOC (n = 271). Both treatment groups experienced improvements in sexual function from baseline ASEX assessments. However at 8 weeks the aripiprazole treatment group reported significantly greater improvement compared with the SOC group (p = 0.007; OC). Although baseline mean serum prolactin levels were similar in the two treatment groups (43.4 mg/dL in the aripiprazole group and 42.3 mg/dL in the SOC group, p = NS) at Week 26 OC, mean decreases in serum prolactin were 34.2 mg/dL in the aripiprazole group, compared with 13.3 mg/dL in the SOC group (p < 0.001).
conclusionThe study findings suggest that aripiprazole has the potential to reduce sexual dysfunction, which in turn might improve patient compliance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.