ArticleChemistry & biology2008
The importance of odorant conformation to the binding and activation of a representative olfactory receptor.
Article in Chemistry & biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 64 citations in OpenAlex.
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- Quantum Smell: Tunneling Mechanisms in Olfaction.Molecules (Basel, Switzerland) · 2025Article
- Decoding deception: the binding affinity of cuttlefish ink on shark smell receptors.G3 (Bethesda, Md.) · 2025Article
- Template-based modeling of insect odorant receptors outperforms AlphaFold3 for ligand binding predictions.Scientific reports · 2024Article
- Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line.PloS one · 2022Article
- Odor coding in the mammalian olfactory epithelium.Cell and tissue research · 2021Review
- Exploring the Characteristics of an Aroma-Blending Mixture by Investigating the Network of Shared Odors and the Molecular Features of Their Related Odorants.Molecules (Basel, Switzerland) · 2020Article
- Widespread receptor-driven modulation in peripheral olfactory coding.Science (New York, N.Y.) · 2020Article
- Peripheral Gene Therapeutic Rescue of an Olfactory Ciliopathy Restores Sensory Input, Axonal Pathfinding, and Odor-Guided Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Carbon chain shape selectivity by the mouse olfactory receptor OR-I7.Organic & biomolecular chemistry · 2018Article
- Functional odor classification through a medicinal chemistry approach.Science advances · 2018Article
- Investigation of the electrophilic reactivity of the biologically active marine sesquiterpenoid onchidal and model compounds.Beilstein journal of organic chemistry · 2018Article
- Combinatorial effects of odorants on mouse behavior.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Phosphoinositide-3-Kinase Is the Primary Mediator of Phosphoinositide-Dependent Inhibition in Mammalian Olfactory Receptor Neurons.Frontiers in cellular neuroscience · 2016Article
- Receptive range analysis of a mouse odorant receptor subfamily.Journal of neurochemistry · 2015Article
- Aldehyde recognition and discrimination by mammalian odorant receptors via functional group-specific hydration chemistry.ACS chemical biology · 2014Article
- The state of the art of odorant receptor deorphanization: a report from the orphanage.The Journal of general physiology · 2014Review
- Diverse applications of electronic-nose technologies in agriculture and forestry.Sensors (Basel, Switzerland) · 2013Review
- Phosphoinositide 3-kinase dependent inhibition as a broad basis for opponent coding in Mammalian olfactory receptor neurons.PloS one · 2013Article
- Pharmacology of mammalian olfactory receptors.Methods in molecular biology (Clifton, N.J.) · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Olfactory receptors (ORs) form a large family of G protein-coupled receptor proteins (GPCRs) responsible for sensing the ambient chemical environment. The molecular recognition strategies used by ORs to detect and distinguish odorant molecules are unclear. Here, we investigated the variable of odorant carbon chain conformation for an established odorant-OR pair: n-octanal and rat OR-I7. A series of conformationally restricted octanal mimics were tested on live olfactory sensory neurons (OSNs). Our results support a model in which unactivated OR-I7 binds aliphatic aldehydes indiscriminately, and then applies conformational and length filters to distinguish agonists from antagonists. Specific conformers are proposed to activate OR-I7 by steric buttressing of an OR activation pocket. Probing endogenously expressed rat OSNs with octanal and constrained mimics furnished evidence that odorant conformation contributes to an odorant's unique olfactory code signature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.