ArticleThe American journal of cardiology2009
A propensity-matched study of the association of peripheral arterial disease with cardiovascular outcomes in community-dwelling older adults.
Article in The American journal of cardiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 87 citations in OpenAlex.
- Clinical Characteristics and Outcomes of Patients with High Ankle-Brachial Index from the IMPACT-ABI Study.PloS one · 2016Trial
- Effect of warfarin on outcomes in septuagenarian patients with atrial fibrillation.The American journal of cardiology · 2012Trial
- Dapagliflozin Improves Angiogenesis after Hindlimb Ischemia through the PI3K-Akt-eNOS Pathway.Biomolecules · 2024Article
- Managing Hypertension in the elderly: What's new?American journal of preventive cardiology · 2020Review
- Reducing residual thrombotic risk in patients with peripheral artery disease: impact of the COMPASS trial.Drugs in context · 2020Review
- Endovascular Revascularization Improves the Central Hemodynamics and Augmentation Index in Patients with Peripheral Artery Disease.Internal medicine (Tokyo, Japan) · 2020Article
- One- to 10-Day Versus 11- to 30-Day All-Cause Readmission and Mortality in Older Patients With Heart Failure.The American journal of cardiology · 2019Article
- Review
- Prediction and Subtyping of Hypertension from Pan-Tissue Transcriptomic and Genetic Analyses.Genetics · 2017Article
- Ankle-brachial Index for the Prognosis of Cardiovascular Disease in Patients with Mild Renal Insufficiency.Internal medicine (Tokyo, Japan) · 2017Article
- Managing Hypertension in the Elderly: What is Different, What is the Same?Current hypertension reports · 2017Review
- Article
- Measurement of blood pressure.Annals of translational medicine · 2017Article
- Collagen-binding nanoparticles for extracellular anti-inflammatory peptide delivery decrease platelet activation, promote endothelial migration, and suppress inflammation.Acta biomaterialia · 2017Article
- Prevention of Collagen-Induced Platelet Binding and Activation by Thermosensitive Nanoparticles.The AAPS journal · 2015Article
- Blood Pressure Goals and Targets in the Elderly.Current treatment options in cardiovascular medicine · 2015Article
- Peripheral vascular disease is associated with increased pulse wave velocity and augmentation index: clinical implications.Journal of clinical hypertension (Greenwich, Conn.) · 2014Article
- Heart failure risk across the spectrum of ankle-brachial index: the ARIC study (Atherosclerosis Risk In Communities).JACC. Heart failure · 2014Observational
- Angiotensin-converting enzyme inhibitors and outcomes in heart failure and preserved ejection fraction.The American journal of medicine · 2013Article
- Severity of peripheral arterial disease is associated with aortic pressure augmentation and subendocardial viability ratio.Journal of clinical hypertension (Greenwich, Conn.) · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The association between peripheral arterial disease (PAD) and outcomes has not been studied in a propensity-matched population of community-dwelling older adults. A public-use copy of the Cardiovascular Health Study (CHS) data was analyzed to test the hypothesis that baseline PAD is associated with increased all-cause mortality and cardiovascular morbidity. Of the 5,795 CHS participants, 5,630 had data on baseline ankle-brachial index, and 767 had PAD, defined as ankle-brachial index <0.9. Propensity scores for PAD were calculated for each participant using 66 baseline covariates and were used to match 679 pairs of participants with and without PAD. Matched Cox regression models were used to estimate associations of PAD with outcomes during a median follow-up period of 7.5 years. Overall, 55% of matched participants died from all causes during 9,958 patient-years of follow-up. All-cause mortality occurred in 61% (rate 8,710/100,000 patient-years) and 50% (rate 6,503/100,000 patient-years) of participants, respectively, with and without PAD (matched hazard ratio for PAD vs no PAD 1.47, 95% confidence interval (CI) 1.23 to 1.76, p <0.0001). Prematch unadjusted, multivariable-adjusted, and propensity-adjusted hazard ratios for PAD-associated all-cause mortality were 2.90 (95% CI 2.61 to 3.21, p <0.0001), 1.53 (95% CI 1.36 to 1.71, p <0.0001), and 1.57 (95% CI 1.39 to 1.78, p <0.0001), respectively. Matched hazard ratios for PAD for incident heart failure and symptomatic PAD were 1.32 (95% CI 1.00 to 1.73, p = 0.052) and 3.92 (95% CI 2.13 to 7.21, p <0.0001), respectively. In conclusion, in a propensity-matched well-balanced population of community-dwelling older adults, baseline PAD was associated with increased all-cause mortality and cardiovascular morbidity.
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