Trial reportPulmonary pharmacology & therapeutics2009
The urge-to-cough and cough motor response modulation by the central effects of nicotine.
Trial report in Pulmonary pharmacology & therapeutics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 59 citations in OpenAlex.
- Trial
- Neural mechanisms of cough: insights from multimodal magnetic resonance imaging-a narrative review.Journal of thoracic disease · 2026Review
- Oral Capsaicin as Treatment for Unexplained Chronic Cough and Airway Symptoms.CHEST pulmonary · 2024Article
- Primary site of constriction during the compression phase of cough in healthy young adults.Respiratory physiology & neurobiology · 2023Article
- Evidence for AlphaThe Journal of pharmacology and experimental therapeutics · 2022Article
- Article
- Mechanisms and Rationale for Targeted Therapies in Refractory and Unexplained Chronic Cough.Clinical pharmacology and therapeutics · 2021Review
- Impact of Tussigenic Stimuli on Perceived Upper Airway Sensation and Motor Cough Response Following Total Laryngectomy.Frontiers in physiology · 2020Article
- Management of Dysphagia in Acquired and Progressive Neurologic Conditions.Seminars in speech and language · 2019Review
- Down-Regulation of Cough during Exercise Is Less Frequent in Healthy Children than Adults. Role of the Development and/or Atopy?Frontiers in physiology · 2017Article
- To Cough or Not to Cough? Examining the Potential Utility of Cough Testing in the Clinical Evaluation of Swallowing.Current physical medicine and rehabilitation reports · 2016Article
- Comparison of Two Methods for Inducing Reflex Cough in Patients With Parkinson's Disease, With and Without Dysphagia.Dysphagia · 2016Article
- Respiratory kinematic and airflow differences between reflex and voluntary cough in healthy young adults.Frontiers in physiology · 2015Article
- Comparison of voluntary and reflex cough effectiveness in Parkinson's disease.Parkinsonism & related disorders · 2014Article
- What is chronic cough in children?Frontiers in physiology · 2014Review
- Sensorimotor circuitry involved in the higher brain control of coughing.Cough (London, England) · 2013Article
- Cough expired volume and airflow rates during sequential induced cough.Frontiers in physiology · 2013Article
- Review: Effect of drugs on human cough reflex sensitivity to inhaled capsaicin.Cough (London, England) · 2012Article
- On the psychology of cough.Lung · 2012Review
- Perspective on the human cough reflex.Cough (London, England) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The urge-to-cough is a respiratory sensation that precedes the cough motor response. Since affective state modulates the perception of respiratory sensations such as dyspnoea, we wanted to test whether nicotine, an anxiolytic, would modulate the urge-to-cough and hence, the cough motor response. We hypothesized that withdrawal from and administration of nicotine in smoking subjects would modulate their anxiety levels, urge-to-cough and cough motor response to capsaicin stimulation. Twenty smoking (SM) adults (8F, 12M; 22+/-3 years; 2.9+/-2.0 pack years) and matched non-smoking (NS) controls (22+/-2 years) were presented with randomized concentrations of capsaicin (0-200 microM) before and after nicotine (SM only) gum and/or placebo (SM and NS) gum. Subjects rated their urge-to-cough using a Borg scale at the end of each capsaicin presentation. Cough number and cough motor pattern were determined from airflow tracings. Subjects completed State-Trait Anxiety Inventory (STAI) questionnaires before and after gum administration. SM subjects that withdrew from cigarette smoking for 12 h exhibited an increase in anxiety scores, a greater number of coughs and higher urge-to-cough ratings compared to NS subjects. Administration of nicotine gum reduced anxiety scores, cough number and urge-to-cough ratings to match the NS subjects. There was no effect of placebo gum on any of the measured parameters in the SM and NS groups. The results from this study suggest that modulation of the central neural state with nicotine withdrawal and administration in young smoking adults is associated with a change in anxiety levels which in turn modulates the perceptual and motor response to irritant cough stimulants.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.