ArticleJournal of ethnopharmacology2009
Extract of the Chinese herbal formula Huo Luo Xiao Ling Dan inhibited adjuvant arthritis in rats.
Article in Journal of ethnopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 89 citations in OpenAlex.
- Huo-Luo-Xiao-Ling (HLXL)-Dan, a Traditional Chinese Medicine, for patients with osteoarthritis of the knee: a multi-site, randomized, double-blind, placebo-controlled phase II clinical trial.Osteoarthritis and cartilage · 2015Trial
- Anti-arthritic appraisal of Acorus calamus L. extracts in complete Freund's adjuvant‑induced arthritic Wistar rats via regulating inflammatory cytokines and OPG/RANKL pathway.Inflammopharmacology · 2026Article
- Article
- Curcumin Co-Encapsulation Potentiates Anti-Arthritic Efficacy of Meloxicam Biodegradable Nanoparticles in Adjuvant-Induced Arthritis Animal Model.Biomedicines · 2023Article
- Danggui Niantong granules ameliorate rheumatoid arthritis by regulating intestinal flora and promoting mitochondrial apoptosis.Pharmaceutical biology · 2022Article
- Anti-arthritic activity and phytochemical composition of "Cao Khai" (Aqueous extracts ofHeliyon · 2022Article
- Anti-arthritic activity ofIranian journal of basic medical sciences · 2021Article
- Evaluation of anti-inflammatory and anti-arthritic property of ethanolic extract ofChinese herbal medicines · 2021Article
- Protective effect of Corynoline on the CFA induced Rheumatoid arthritis via attenuation of oxidative and inflammatory mediators.Molecular and cellular biochemistry · 2021Article
- Natural Products for the Treatment of Autoimmune Arthritis: Their Mechanisms of Action, Targeted Delivery, and Interplay with the Host Microbiome.International journal of molecular sciences · 2018Review
- Ipomoea batatas L. Lam. ameliorates acute and chronic inflammations by suppressing inflammatory mediators, a comprehensive exploration using in vitro and in vivo models.BMC complementary and alternative medicine · 2018Article
- Salvianolic Acid B Suppresses Inflammatory Mediator Levels by Downregulating NF-κB in a Rat Model of Rheumatoid Arthritis.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- The Ethanolic Extract ofIranian journal of pharmaceutical research : IJPR · 2018Article
- Effect of new polyherbal formulations DF1911, DF2112 and DF2813 on CFA induced inflammation in rat model.BMC complementary and alternative medicine · 2017Article
- A computational and functional study elicits the ameliorating effect of the Chinese herbal formula Huo Luo Xiao Ling Dan on experimental ischemia-induced myocardial injury in rats via inhibition of apoptosis.Drug design, development and therapy · 2015Article
- Scientific basis of botanical medicine as alternative remedies for rheumatoid arthritis.Clinical reviews in allergy & immunology · 2013Review
- Mediators of inflammation-induced bone damage in arthritis and their control by herbal products.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Microarray analysis reveals the molecular basis of antiarthritic activity of huo-luo-xiao-ling dan.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Chinese Herbal Formula Huo-Luo-Xiao-Ling Dan Protects against Bone Damage in Adjuvant Arthritis by Modulating the Mediators of Bone Remodeling.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Modified huo-luo-xiao-ling dan suppresses adjuvant arthritis by inhibiting chemokines and matrix-degrading enzymes.Evidence-based complementary and alternative medicine : eCAM · 2012Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
ethnopharmacological relevanceThe herbal formula Huo Luo Xiao Ling Dan (HLXL) and its modifications have been used in traditional Chinese medicine for about one hundred years to alleviate pain and inflammation.
aimTo investigate the effects of HLXL on complete Freund's adjuvant (CFA)-induced multiple-joint arthritis in rats. MATERIALS AND
methodsMale Lewis rats, 190-210 g, were immunized subcutaneously at the base of the tail with 200 microl of heat-killed Mycobacterium tuberculosis in mineral oil (5 mg/ml). HLXL (2.30 and 4.60 g/kg) or vehicle control (n=8 per group) was administered orally (i.g.) once a day between days 16 and 25 post-CFA injection. The rats were observed for signs of arthritis with arthritic changes (erythema, edema, induration) being scored on a scale of 0-4 of increasing severity using a standard scoring system. The maximum arthritis score per rat was 16. A plethysmometer was used to measure edema volume in each paw. Adverse effects of HLXL were monitored by closely observing the animals for unusual behavioral changes. Levels of tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) in local tissue were measured by enzyme-linked immunosorbent assay on day 25 post-CFA.
resultsHLXL significantly decreased arthritis scores between days 23-25 in the 2.30 g/kg group and 21-25 in the 4.60 g/kg group (p<0.05). It reduced paw edema on days 22 and 24 in the 2.30 g/kg group and on days 20, 22 and 24 in the 4.60 g/kg group compared to control (p<0.05). Local tissue TNF-alpha and IL-1beta levels on day 25 post-CFA injection were significantly (p<0.05) lower in rats treated with HLXL than in control rats. No observable adverse effects were found.
conclusionThe data suggest that HLXL produces significant anti-arthritic effects that may be mediated by suppressing pro-inflammatory cytokines, and it appears to be safe.
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