ArticleFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2009
Analysis of gene expression changes of drug metabolizing enzymes in the livers of F344 rats following oral treatment with kava extract.
Article in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
- An Updated Review on the Psychoactive, Toxic and Anticancer Properties of Kava.Journal of clinical medicine · 2022Review
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity.Journal of environmental science and health. Part C, Toxicology and carcinogenesis · 2021Article
- The role of hepatic cytochrome P450s in the cytotoxicity of sertraline.Archives of toxicology · 2020Article
- The role of hepatic cytochrome P450s in the cytotoxicity of dronedarone.Archives of toxicology · 2018Article
- DNA Microarray-Based Screening and Characterization of Traditional Chinese Medicine.Microarrays (Basel, Switzerland) · 2017Review
- The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity.Toxicology letters · 2016Article
- Hepatotoxicity Induced by "the 3Ks": Kava, Kratom and Khat.International journal of molecular sciences · 2016Review
- Flavokawains a and B in kava, not dihydromethysticin, potentiate acetaminophen-induced hepatotoxicity in C57BL/6 mice.Chemical research in toxicology · 2014Article
- Sertraline induces endoplasmic reticulum stress in hepatic cells.Toxicology · 2014Article
- Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Endoplasmic reticulum stress in drug- and environmental toxicant-induced liver toxicity.Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews · 2014Review
- Mechanism study of goldenseal-associated DNA damage.Toxicology letters · 2013Article
- Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1.Toxicological sciences : an official journal of the Society of Toxicology · 2011Article
- Liver toxicity and carcinogenicity in F344/N rats and B6C3F1 mice exposed to Kava Kava.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2011Article
- Two-year toxicity and carcinogenicity studies of Panax ginseng in Fischer 344 rats and B6C3F1 mice.The American journal of Chinese medicine · 2011Article
- Abnormal gene expression in cerebellum of Npc1-/- mice during postnatal development.Brain research · 2010Article
- Ginkgo biloba extract induces gene expression changes in xenobiotics metabolism and the Myc-centered network.Omics : a journal of integrative biology · 2010Article
- Gene expression profiling in male B6C3F1 mouse livers exposed to kava identifies--changes in drug metabolizing genes and potential mechanisms linked to kava toxicity.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2010Article
- Gene expression profiling as an initial approach for mechanistic studies of toxicity and tumorigenicity of herbal plants and herbal dietary supplements.Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews · 2010Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
The association of kava product use with liver-related risks has prompted regulatory action in many countries. We studied the changes in gene expression of drug metabolizing enzymes in the livers of Fischer 344 male rats administered kava extract by gavage for 14 weeks. Analysis of 22,226 genes revealed that there were 14, 41, 110, 386, and 916 genes significantly changed in the 0.125, 0.25, 0.5, 1.0, and 2.0 g/kg treatment groups, respectively. There were 16 drug metabolizing genes altered in all three high-dose treatment groups, among which seven genes belong to cytochrome P450 isozymes. While gene expression of Cyp1a1, 1a2, 2c6, 3a1, and 3a3 increased; Cyp 2c23 and 2c40 decreased, all in a dose-dependent manner. Real-time PCR analyses of several genes verified these results. Our results indicate that kava extract can significantly modulate drug metabolizing enzymes, particularly the CYP isozymes, which could cause herb-drug interactions and may potentially lead to hepatotoxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.